Histopathology and diagnostic approaches to the myeloproliferative neoplasms

Christina Salazar, Sanjeev M. Balamohan, Patrick D. Millikan, Wendy H. Raskind, Melissa A. Kacena

Research output: Chapter in Book/Report/Conference proceedingChapter


Myeloproliferative neoplasms (MPNs) are diseases in which clonal cells of one or more myeloid lineages proliferate in the bone marrow. Elevated megakaryopoeisis is prominent among these disorders and contributes to essential thrombocythemia, primary myelofibrosis, polycythemia vera, and chronic myelogenous leukemia, which are considered the most common MPNs. Acute megakaryoblastic leukemia is also characterized by expansion of the megarkaryocytic lineage. The diseases all share a similar clinical course, often exhibiting splenomegaly, hepatomegaly, thrombocytosis, and various clotting and bleeding symptoms. The similarity of symptoms necessitates a combination of histological, clinical, and cytogenetic tests in order to make an accurate diagnosis. The V617 JAK2 mutation has been identified in most patients with polycythemia vera, and is also present in a subset of patients with essential thrombocythemia and primary myelofibrosis. Novel mutations are also being studied for their relevance to the pathogenesis of MPNs and may allow for further differentiation of the diseases. However, bone marrow histopathology may still serve as the most discriminating method to diagnose these disorders. The MPNs all display distinct megakaryocyte morphology and the bone marrow histopathology allows for investigation of proliferation of other hematopoietic lineages.

Original languageEnglish (US)
Title of host publicationMyeloproliferative Disorders
Subtitle of host publicationSymptoms, Risk Factors and Treatment Options
PublisherNova Science Publishers, Inc.
Number of pages19
ISBN (Electronic)9781633212022
ISBN (Print)9781633212015
StatePublished - Jul 1 2014

ASJC Scopus subject areas

  • Social Sciences(all)

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    Salazar, C., Balamohan, S. M., Millikan, P. D., Raskind, W. H., & Kacena, M. A. (2014). Histopathology and diagnostic approaches to the myeloproliferative neoplasms. In Myeloproliferative Disorders: Symptoms, Risk Factors and Treatment Options (pp. 55-73). Nova Science Publishers, Inc..