This review provides a brief account of the more pertinent recent reports related to the histopathology of transitional cell carcinoma of the urinary bladder. The recent literature continues to emphasize the importance of accurate and reproducible pathologic characterization of transitional cell carcinoma, including architectural growth patterns, grading, and detailed pathologic staging. There is particular interest and concern regarding the subset of patients with superficially invasive (pT1) high-grade transitional cell carcinoma from a management and outcome perspective. Within the rapidly growing field of searching for additional prognostic parameters in transitional cell carcinoma and other solid tumors, reproducible and uniformly communicated morphologic characteristics remain the cornerstone for the optimal management of bladder cancer patients.
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