Histopathology predicts the mechanism of stone formation

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

About 5% of American women and 12% of men will develop a kidney stone at some time in their life and these numbers appear to be on the rise. Despite years of scientific research into the mechanisms of stone formation and growth, limited advances have been made until recently. Randall's original observations and thoughts on the mechanisms for kidney stone formation have been validated for idiopathic calcium oxalate stone formers (ICSF) but not for most other stone forming groups. Our current studies on selected groups of human stone formers using intraoperative papillary biopsies has shown overwhelming evidence for the presence of Randall's plaque in ICSF and that stone formation and growth are exclusively linked to its availability to urinary ions and proteins. Intense investigation of the plaque-stone junction is needed if we are to understand the factors leading to the overgrowth process on exposed regions of plaque. Such information should allow the development of treatment strategies to block stone formation in ICSF patients. Patients who form brushite stones, or who form apatite stones because of distal renal tubular acidosis (dRTA), or patients with calcium oxalale stones due to obesity bypass procedures, or patients with cystinuria. get plugged inner medullary collecting ducts (IMCD) which leads to total destruction of the lining cells and focal sites of interstitial fibrosis. These stone formers have plaque but at levels equal to or below non-stone formers, which would suggest that they form stones by a different mechanism than do ICSF patients.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages15-25
Number of pages11
Volume900
StatePublished - 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Other

Other1st Annual International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period11/2/0611/3/06

Fingerprint

rocks
calcium
oxalates
kidney stones
acidosis
obesity
fibrosis
bypasses
apatites
linings
ducts
destruction
availability
interstitials
proteins

Keywords

  • Kidney stones
  • Papilla biopsies
  • Randall's plaque

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Evan, A. (2007). Histopathology predicts the mechanism of stone formation. In AIP Conference Proceedings (Vol. 900, pp. 15-25)

Histopathology predicts the mechanism of stone formation. / Evan, Andrew.

AIP Conference Proceedings. Vol. 900 2007. p. 15-25.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Evan, A 2007, Histopathology predicts the mechanism of stone formation. in AIP Conference Proceedings. vol. 900, pp. 15-25, 1st Annual International Urolithiasis Research Symposium, Indianapolis, IN, United States, 11/2/06.
Evan A. Histopathology predicts the mechanism of stone formation. In AIP Conference Proceedings. Vol. 900. 2007. p. 15-25
Evan, Andrew. / Histopathology predicts the mechanism of stone formation. AIP Conference Proceedings. Vol. 900 2007. pp. 15-25
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