History of glial cell line-derived neurotrophic factor (GDNF) and its use for spinal cord injury repair

Melissa J. Walker, Xiao-Ming Xu

Research output: Contribution to journalReview article

4 Scopus citations


Following an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial cell line-derived neurotrophic factor (GDNF) and its application, in combination with other factors and cell transplantations, for repairing the injured spinal cord. As studies of recent decades strongly suggest that combinational treatment approaches hold the greatest therapeutic potential for the central nervous system (CNS) trauma, future directions of combinational therapies will also be discussed.

Original languageEnglish (US)
Article number109
JournalBrain Sciences
Issue number6
StatePublished - Jun 13 2018



  • Astrogliosis
  • Axonal regeneration
  • Combinational therapies
  • CRET
  • GFRα-1
  • Glial cell line-derived neurotrophic factor (GDNF)
  • Neuroprotection
  • Neurotrauma
  • Schwann cells
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

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