HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures

Barbara A. Bennett, Daniel Rusyniak, Charlotte K. Hollingsworth

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

HIV-1-associated cognitive/motor dysfunction is a frequent neurological complication of acquired immunodeficiency syndrome (AIDS) and has been termed AIDS dementia complex (ADC. The HIV-1 envelope glycoprotein gp120 has been implicated in producing brain injury associated with ADC. The purpose of the present study was to determine if gp120-induced neurotoxicity is associated with damage to dopaminergic systems. Exposure of rat midbrain dopamine cultures to gp120 for 3 days reduced the ability of dopaminergic cells to transport this amine and also resulted in a reduction in dopamine neuron process length while it did not alter either dopamine cell number or the total number of neuronal cells. These detrimental effects of gp120 were prevented by an NMDA receptor antagonist (MK-801) or by preincubation with anti-gp120 antibody. These results suggest that dopaminergic neuronal damage may contribute to the manifestations of AIDS dementia complex.

Original languageEnglish (US)
Pages (from-to)168-176
Number of pages9
JournalBrain Research
Volume705
Issue number1-2
DOIs
StatePublished - Dec 24 1995
Externally publishedYes

Fingerprint

Mesencephalon
HIV-1
Dopamine
Acquired Immunodeficiency Syndrome
Dementia
Cell Count
HIV Envelope Protein gp120
Aptitude
Dizocilpine Maleate
Dopaminergic Neurons
N-Methyl-D-Aspartate Receptors
Brain Injuries
Amines
Anti-Idiotypic Antibodies

Keywords

  • Dopamine uptake
  • gp120
  • HIV-1
  • Midbrain culture
  • Neurotoxicity
  • NMDA

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures. / Bennett, Barbara A.; Rusyniak, Daniel; Hollingsworth, Charlotte K.

In: Brain Research, Vol. 705, No. 1-2, 24.12.1995, p. 168-176.

Research output: Contribution to journalArticle

Bennett, Barbara A. ; Rusyniak, Daniel ; Hollingsworth, Charlotte K. / HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures. In: Brain Research. 1995 ; Vol. 705, No. 1-2. pp. 168-176.
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