HIV infection and its impact on fetal outcomes among women of advanced maternal age

A propensity score weighted matching approach

Hamisu M. Salihu, Mulubrhan F. Mogos, Euna M. August, Sharon Dejoy, Cara De La Cruz, Amina P. Alio, Phillip J. Marty

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Advanced maternal age (AMA) and HIV status have been investigated separately for their influence on infant outcomes. Both are associated with adverse fetal growth outcomes, including low birth weight (LBW) and preterm birth (PTB). However, the impact of the cooccurrence of these factors in relation to birth outcomes remains relatively understudied. We analyzed Florida hospital discharge data linked to vital records. The study population consisted of women who had a singleton live birth between 1998 and 2007 (N=1,687,176). The exposure variables were HIV infection and maternal age, while the outcomes of interest were LBW, PTB, and small for gestational age (SGA). We matched HIV-positive women to HIV-negative women on selected variables using propensity scores. To approximate relative risks, we computed adjusted odds ratios (AOR) and 95% confidence intervals (CI) generated from logistic regression models and accounted for the matched design using the generalized estimating equations framework. After adjusting for demographic variables, clinical conditions, and route of birth, the risks of LBW, PTB, and SGA remained significant for HIV-positive women, regardless of age. HIV-positive women of AMA (≥35 years) were more likely to have infants of LBW (AOR=1.73, 95% CI=1.37-2.18), PTB (AOR=1.35, 95% CI: 1.06-1.71), and SGA (AOR=1.52, 95% CI=1.22-1.89), compared to uninfected mothers of younger age (

Original languageEnglish (US)
Pages (from-to)581-587
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume29
Issue number3
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

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Propensity Score
Maternal Age
HIV Infections
Premature Birth
Low Birth Weight Infant
HIV
Odds Ratio
Confidence Intervals
Gestational Age
Logistic Models
Parturition
Live Birth
Fetal Development
Mothers
Demography
Population

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

HIV infection and its impact on fetal outcomes among women of advanced maternal age : A propensity score weighted matching approach. / Salihu, Hamisu M.; Mogos, Mulubrhan F.; August, Euna M.; Dejoy, Sharon; De La Cruz, Cara; Alio, Amina P.; Marty, Phillip J.

In: AIDS Research and Human Retroviruses, Vol. 29, No. 3, 01.03.2013, p. 581-587.

Research output: Contribution to journalArticle

Salihu, Hamisu M. ; Mogos, Mulubrhan F. ; August, Euna M. ; Dejoy, Sharon ; De La Cruz, Cara ; Alio, Amina P. ; Marty, Phillip J. / HIV infection and its impact on fetal outcomes among women of advanced maternal age : A propensity score weighted matching approach. In: AIDS Research and Human Retroviruses. 2013 ; Vol. 29, No. 3. pp. 581-587.
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