HIV-related lung disorders

Homer Twigg, Kenneth S. Knox

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Highly active antiretroviral therapy (HAART) has dramatically altered the spectrum of morbidity and mortality in HIV-infected patients. This has been attributed to improvements in the lung microenvironment leading to enhanced pulmonary immunity, either by preventing the progressive loss of immune function or by actually promoting immune restoration. However, these changes have been accompanied by the recognition of new pulmonary complications in HIV-infected subjects, especially those associated with immune reconstitution. In this review, we will describe how HIV infection alters the normal pulmonary environment, highlight the effect of HAART on these perturbations and discuss potential complications of HAART in the lung, focusing on the pulmonary immune reconstitution inflammatory syndrome (IRIS).

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalDrug Discovery Today: Disease Mechanisms
Volume4
Issue number2
DOIs
StatePublished - Jun 2007

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HIV
Lung
Highly Active Antiretroviral Therapy
Immune Reconstitution Inflammatory Syndrome
HIV Infections
Immunity
Morbidity
Mortality

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

HIV-related lung disorders. / Twigg, Homer; Knox, Kenneth S.

In: Drug Discovery Today: Disease Mechanisms, Vol. 4, No. 2, 06.2007, p. 95-101.

Research output: Contribution to journalArticle

Twigg, Homer ; Knox, Kenneth S. / HIV-related lung disorders. In: Drug Discovery Today: Disease Mechanisms. 2007 ; Vol. 4, No. 2. pp. 95-101.
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