Holographic microrheology of polysaccharides from Streptococcus mutans biofilms

Fook Chiong Cheong, Simone Duarte, Sang Hyuk Lee, David G. Grier

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

We use three-dimensional holographic particle tracking to perform microrheological measurements of model gelled media, including the polysaccharide pellicle of dental biofilms created by the common cariogenic oral pathogen Streptococcus mutans. Nanometer-resolution video-rate holographic tracking of embedded colloidal spheres provides accurate measurements of the gels' complex viscoelastic moduli, including insights into these properties' heterogeneity. When applied to polysaccharides of S. mutans biofilms, these techniques promise quantitative microscopic assays for candidate therapeutic agents against cariogenic dental biofilms.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalRheologica Acta
Volume48
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Biofilms
  • Microrheology
  • Polysaccharide gel
  • Streptococcus mutans
  • Video holographic microscopy

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

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