Homing, cell cycle kinetics and fate of transplanted hematopoietic stem cells

E. F. Srour, A. Jetmore, F. M. Wolber, P. A. Plett, R. Abonour, M. C. Yoder, C. M. Orschell-Traycoff

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Homing of transplanted hematopoietic stem cells to recipient bone marrow is a critical step in engraftment and initiation of marrow reconstitution. At present, only partial understanding of the cellular and molecular mechanisms governing homing exists. Likewise, only an incomplete list of adhesion molecules implicated in directing the trafficking of stem cells to the marrow microenvironment is available. Opposing hypotheses that attribute homing to an orderly and orchestrated cascade of events or to random migration of circulating cells find ample experimental support. Also unsettled is the fate of marrow-homed cells shortly after transplantation and the rapidity at which they begin to proliferate in their new marrow microenvironment. The limited number of studies in this field and disparities in their experimental design intensifies the confusion surrounding these critical aspects of stem cell biology. However, this area of research is moving forward rapidly and results capable of clarifying many of these issues are forthcoming.

Original languageEnglish (US)
Pages (from-to)1681-1684
Number of pages4
JournalLeukemia
Volume15
Issue number11
DOIs
StatePublished - 2001

Keywords

  • Cell cycle kinetics
  • Engraftment
  • Homing
  • Trafficking

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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