Homing, cell cycle kinetics and fate of transplanted hematopoietic stem cells

Edward Srour, A. Jetmore, F. M. Wolber, P. A. Plett, Rafat Abonour, Mervin Yoder, Christie Orschell

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Homing of transplanted hematopoietic stem cells to recipient bone marrow is a critical step in engraftment and initiation of marrow reconstitution. At present, only partial understanding of the cellular and molecular mechanisms governing homing exists. Likewise, only an incomplete list of adhesion molecules implicated in directing the trafficking of stem cells to the marrow microenvironment is available. Opposing hypotheses that attribute homing to an orderly and orchestrated cascade of events or to random migration of circulating cells find ample experimental support. Also unsettled is the fate of marrow-homed cells shortly after transplantation and the rapidity at which they begin to proliferate in their new marrow microenvironment. The limited number of studies in this field and disparities in their experimental design intensifies the confusion surrounding these critical aspects of stem cell biology. However, this area of research is moving forward rapidly and results capable of clarifying many of these issues are forthcoming.

Original languageEnglish
Pages (from-to)1681-1684
Number of pages4
JournalLeukemia
Volume15
Issue number11
StatePublished - 2001

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Hematopoietic Stem Cells
Cell Cycle
Bone Marrow
Stem Cells
Cell Movement
Cell Biology
Research Design
Transplantation
Research

Keywords

  • Cell cycle kinetics
  • Engraftment
  • Homing
  • Trafficking

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Homing, cell cycle kinetics and fate of transplanted hematopoietic stem cells. / Srour, Edward; Jetmore, A.; Wolber, F. M.; Plett, P. A.; Abonour, Rafat; Yoder, Mervin; Orschell, Christie.

In: Leukemia, Vol. 15, No. 11, 2001, p. 1681-1684.

Research output: Contribution to journalArticle

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