Homocysteine levels and dementia risk in Yoruba and African Americans

Hugh Hendrie, Olusegun Baiyewu, Kathleen A. Lane, Christianna Purnell, Sujuan Gao, Ann Hake, Adesola Ogunniyi, Oye Gureje, Frederick Unverzagt, Jill Murrell, Mark A. Deeg, Kathleen Hall

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

ABSTRACT Background: High levels of homocysteine have been associated with increased risk for dementia although results have been inconsistent. There are no reported studies from the developing world including Africa. Methods: In this longitudinal study of two community-dwelling cohorts of elderly Yoruba and African Americans, levels of homocysteine, vitamin B12 and folate were measured from blood samples taken in 2001. These levels were compared in two groups, participants who developed incident dementia in the follow-up until 2009 (59 Yoruba and 101 African Americans) and participants who were diagnosed as cognitively normal or in the good performance category at their last follow-up (760 Yoruba and 811 African Americans). Homocysteine levels were divided into quartiles for each site. Results: After adjusting for age, education, possession of ApoE, smoking, and time of enrollment the higher quartiles of homocysteine were associated with a non-significant increase in dementia risk in the Yoruba (homocysteine quartile 4 vs. 1 OR: 2.19, 95% CI 0.95-5.07, p = 0.066). For the African Americans, there was a similar but non-significant relationship between higher homocysteine levels and dementia risk. There were no significant relationships between levels of vitamin B12 and folate and incident dementia in either site although folate levels were lower and vitamin B12 levers were higher in the Yoruba than in the African Americans. Conclusions: Increased homocysteine levels were associated with a similar but non-significant increase in dementia risk for both Yoruba and African Americans despite significant differences in folate levels between the two sites.

Original languageEnglish
Pages (from-to)1859-1866
Number of pages8
JournalInternational Psychogeriatrics
Volume25
Issue number11
DOIs
StatePublished - Nov 2013

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Homocysteine
African Americans
Dementia
Folic Acid
Vitamin B 12
Independent Living
Apolipoproteins E
Longitudinal Studies
Smoking
Education

Keywords

  • African Americans
  • Alzheimer's disease
  • dementia
  • homocysteine
  • Yoruba

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Gerontology
  • Clinical Psychology

Cite this

Homocysteine levels and dementia risk in Yoruba and African Americans. / Hendrie, Hugh; Baiyewu, Olusegun; Lane, Kathleen A.; Purnell, Christianna; Gao, Sujuan; Hake, Ann; Ogunniyi, Adesola; Gureje, Oye; Unverzagt, Frederick; Murrell, Jill; Deeg, Mark A.; Hall, Kathleen.

In: International Psychogeriatrics, Vol. 25, No. 11, 11.2013, p. 1859-1866.

Research output: Contribution to journalArticle

Hendrie, Hugh ; Baiyewu, Olusegun ; Lane, Kathleen A. ; Purnell, Christianna ; Gao, Sujuan ; Hake, Ann ; Ogunniyi, Adesola ; Gureje, Oye ; Unverzagt, Frederick ; Murrell, Jill ; Deeg, Mark A. ; Hall, Kathleen. / Homocysteine levels and dementia risk in Yoruba and African Americans. In: International Psychogeriatrics. 2013 ; Vol. 25, No. 11. pp. 1859-1866.
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abstract = "ABSTRACT Background: High levels of homocysteine have been associated with increased risk for dementia although results have been inconsistent. There are no reported studies from the developing world including Africa. Methods: In this longitudinal study of two community-dwelling cohorts of elderly Yoruba and African Americans, levels of homocysteine, vitamin B12 and folate were measured from blood samples taken in 2001. These levels were compared in two groups, participants who developed incident dementia in the follow-up until 2009 (59 Yoruba and 101 African Americans) and participants who were diagnosed as cognitively normal or in the good performance category at their last follow-up (760 Yoruba and 811 African Americans). Homocysteine levels were divided into quartiles for each site. Results: After adjusting for age, education, possession of ApoE, smoking, and time of enrollment the higher quartiles of homocysteine were associated with a non-significant increase in dementia risk in the Yoruba (homocysteine quartile 4 vs. 1 OR: 2.19, 95{\%} CI 0.95-5.07, p = 0.066). For the African Americans, there was a similar but non-significant relationship between higher homocysteine levels and dementia risk. There were no significant relationships between levels of vitamin B12 and folate and incident dementia in either site although folate levels were lower and vitamin B12 levers were higher in the Yoruba than in the African Americans. Conclusions: Increased homocysteine levels were associated with a similar but non-significant increase in dementia risk for both Yoruba and African Americans despite significant differences in folate levels between the two sites.",
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AU - Purnell, Christianna

AU - Gao, Sujuan

AU - Hake, Ann

AU - Ogunniyi, Adesola

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AU - Deeg, Mark A.

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N2 - ABSTRACT Background: High levels of homocysteine have been associated with increased risk for dementia although results have been inconsistent. There are no reported studies from the developing world including Africa. Methods: In this longitudinal study of two community-dwelling cohorts of elderly Yoruba and African Americans, levels of homocysteine, vitamin B12 and folate were measured from blood samples taken in 2001. These levels were compared in two groups, participants who developed incident dementia in the follow-up until 2009 (59 Yoruba and 101 African Americans) and participants who were diagnosed as cognitively normal or in the good performance category at their last follow-up (760 Yoruba and 811 African Americans). Homocysteine levels were divided into quartiles for each site. Results: After adjusting for age, education, possession of ApoE, smoking, and time of enrollment the higher quartiles of homocysteine were associated with a non-significant increase in dementia risk in the Yoruba (homocysteine quartile 4 vs. 1 OR: 2.19, 95% CI 0.95-5.07, p = 0.066). For the African Americans, there was a similar but non-significant relationship between higher homocysteine levels and dementia risk. There were no significant relationships between levels of vitamin B12 and folate and incident dementia in either site although folate levels were lower and vitamin B12 levers were higher in the Yoruba than in the African Americans. Conclusions: Increased homocysteine levels were associated with a similar but non-significant increase in dementia risk for both Yoruba and African Americans despite significant differences in folate levels between the two sites.

AB - ABSTRACT Background: High levels of homocysteine have been associated with increased risk for dementia although results have been inconsistent. There are no reported studies from the developing world including Africa. Methods: In this longitudinal study of two community-dwelling cohorts of elderly Yoruba and African Americans, levels of homocysteine, vitamin B12 and folate were measured from blood samples taken in 2001. These levels were compared in two groups, participants who developed incident dementia in the follow-up until 2009 (59 Yoruba and 101 African Americans) and participants who were diagnosed as cognitively normal or in the good performance category at their last follow-up (760 Yoruba and 811 African Americans). Homocysteine levels were divided into quartiles for each site. Results: After adjusting for age, education, possession of ApoE, smoking, and time of enrollment the higher quartiles of homocysteine were associated with a non-significant increase in dementia risk in the Yoruba (homocysteine quartile 4 vs. 1 OR: 2.19, 95% CI 0.95-5.07, p = 0.066). For the African Americans, there was a similar but non-significant relationship between higher homocysteine levels and dementia risk. There were no significant relationships between levels of vitamin B12 and folate and incident dementia in either site although folate levels were lower and vitamin B12 levers were higher in the Yoruba than in the African Americans. Conclusions: Increased homocysteine levels were associated with a similar but non-significant increase in dementia risk for both Yoruba and African Americans despite significant differences in folate levels between the two sites.

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