Hormonal control of calcium homeostasis

Gregory R. Mundy, Theresa A. Guise

Research output: Contribution to journalArticle

128 Scopus citations


Calcium homeostasis in the extracellular fluid is tightly controlled and defended physiologically. Hypercalcemia always represents considerable underlying pathology and occurs when the hormonal control of calcium homeostasis is overwhelmed. The major hormones that are responsible for normal calcium homeostasis are parathyroid hormone and 1,25-dihydroxyvitamin D; these hormones control extracellular fluid calcium on a chronic basis. Over- or underproduction of these hormones or the tumor peptide, parathyroid hormone-related peptide, are the major causes of aberrant extracellular fluid calcium concentrations. These hormonal defense mechanisms are reviewed here.

Original languageEnglish (US)
Pages (from-to)1347-1352
Number of pages6
JournalClinical chemistry
Issue number8 II
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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    Mundy, G. R., & Guise, T. A. (1999). Hormonal control of calcium homeostasis. Clinical chemistry, 45(8 II), 1347-1352.