Hormonal control of glycogen metabolism.

J. Larner, Peter Roach, L. C. Huang, G. Brooker, F. Murad, R. Hazen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In summary, we have presented evidence which relates to the action pathway of hormonal control of glycogen metabolism. In the case of insulin, there are changes demonstrable in the cyclic AMP-dependent protein kinase and also in the phosphoprotein phosphatase, under conditions where no direct relationship to either cyclic AMP or cyclic GMP levels are measurable. Therefore, a new unknown intermediate or second messenger system is again proposed. An insulin-generated labile compound(s) which inhibits the protein kinase has been discovered. This may function as an intermediate. Finally, the fact that the glycogen synthase system clearly differs from phosphorylase in its regulation by covalent phosphorylation is discussed. Synthase is now accepted as a multiply phosphorylated subunit, in contrast to phosphorylase which is singly phosphorylated. The inherent theoretical advantages of multiple phosphorylation over single phosphorylation are considered. The advantages of a multistate over a two-state model of enzyme interconversion are mentioned. The importance of the multiple phosphorylations interacting in a nonlinear manner with the control by cellular metabolites is in the explanation of how a small change in covalent phosphorylation signalled by a hormone can be translated in the cell milieu into a much larger change in rate.

Original languageEnglish
Pages (from-to)103-123
Number of pages21
JournalAdvances in Experimental Medicine and Biology
Volume111
StatePublished - 1979
Externally publishedYes

Fingerprint

Phosphorylation
Glycogen
Metabolism
Phosphorylases
Insulin
Glycogen Synthase
Phosphoprotein Phosphatases
Cyclic GMP
Second Messenger Systems
Metabolites
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Protein Kinases
Hormones
Enzymes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Larner, J., Roach, P., Huang, L. C., Brooker, G., Murad, F., & Hazen, R. (1979). Hormonal control of glycogen metabolism. Advances in Experimental Medicine and Biology, 111, 103-123.

Hormonal control of glycogen metabolism. / Larner, J.; Roach, Peter; Huang, L. C.; Brooker, G.; Murad, F.; Hazen, R.

In: Advances in Experimental Medicine and Biology, Vol. 111, 1979, p. 103-123.

Research output: Contribution to journalArticle

Larner, J, Roach, P, Huang, LC, Brooker, G, Murad, F & Hazen, R 1979, 'Hormonal control of glycogen metabolism.', Advances in Experimental Medicine and Biology, vol. 111, pp. 103-123.
Larner J, Roach P, Huang LC, Brooker G, Murad F, Hazen R. Hormonal control of glycogen metabolism. Advances in Experimental Medicine and Biology. 1979;111:103-123.
Larner, J. ; Roach, Peter ; Huang, L. C. ; Brooker, G. ; Murad, F. ; Hazen, R. / Hormonal control of glycogen metabolism. In: Advances in Experimental Medicine and Biology. 1979 ; Vol. 111. pp. 103-123.
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