Hormonal Effects on Bone Cells

Teresita Bellido, Kathleen M. Hill Gallant

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

This chapter focuses on the direct effects of systemic hormones on the skeleton. Parathyroid hormone increases bone formation and resorption by acting through receptors expressed in cells of the osteoblastic lineage, and exerts catabolic or anabolic effects depending on the mechanism of elevation (continuous or intermittent). The sex steroids, androgens and estrogens, protect the growing and mature skeleton through receptors expressed in osteoblasts, as well as in osteoclasts, by maintaining the balance between bone formation and resorption. Glucocorticoids, when present in excess due to endogenous elevation or to administration as immunosuppressant therapy, have deleterious effects on bone resulting from acceleration of bone resorption, inhibition of bone formation, and increased bone fragility. Other hormones, such as thyroid hormone, growth hormone, insulin, 1,25-dihydroxyvitamin D3, and leptin affect bone development and homeostasis of the mature skeleton by acting on bone cells of both mesenchymal and hematopoietic lineages.

Original languageEnglish
Title of host publicationBasic and Applied Bone Biology
PublisherElsevier Inc.
Pages299-314
Number of pages16
ISBN (Print)9780124160156
DOIs
StatePublished - Aug 12 2013

Fingerprint

Bone Resorption
Osteogenesis
Skeleton
Bone and Bones
Hormones
Anabolic Agents
Calcitriol
Bone Development
Cell Lineage
Osteoclasts
Immunosuppressive Agents
Leptin
Parathyroid Hormone
Osteoblasts
Thyroid Hormones
Glucocorticoids
Androgens
Growth Hormone
Estrogens
Homeostasis

Keywords

  • Androgens
  • Estrogens
  • Glucocorticoids
  • Growth hormone
  • Insulin
  • Leptin
  • Parathyroid hormone
  • Thyroid hormone
  • Vitamin D3

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Cite this

Bellido, T., & Hill Gallant, K. M. (2013). Hormonal Effects on Bone Cells. In Basic and Applied Bone Biology (pp. 299-314). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-416015-6.00015-0

Hormonal Effects on Bone Cells. / Bellido, Teresita; Hill Gallant, Kathleen M.

Basic and Applied Bone Biology. Elsevier Inc., 2013. p. 299-314.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bellido, T & Hill Gallant, KM 2013, Hormonal Effects on Bone Cells. in Basic and Applied Bone Biology. Elsevier Inc., pp. 299-314. https://doi.org/10.1016/B978-0-12-416015-6.00015-0
Bellido T, Hill Gallant KM. Hormonal Effects on Bone Cells. In Basic and Applied Bone Biology. Elsevier Inc. 2013. p. 299-314 https://doi.org/10.1016/B978-0-12-416015-6.00015-0
Bellido, Teresita ; Hill Gallant, Kathleen M. / Hormonal Effects on Bone Cells. Basic and Applied Bone Biology. Elsevier Inc., 2013. pp. 299-314
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