Hormonal suppression of mini-puberty in a neonate with mosaic 45X/46XY disorder of sexual development

Research output: Contribution to journalArticle

Abstract

Disorders of Sex Development (DSD) are some of the most controversial and challenging conditions that pediatric urologists treat. This may be especially true in mosaic 45X/46XY DSD, due to the inability to ascertain in the neonatal period which gender identity will best suit a given child with this condition. It has therefore been proposed to forgo any irreversible surgical interventions. In order to address the concern of early testosterone production in a nonsurgical manner we describe a case in which we treat a patient with a GnRH agonist to block the early physiologic rise in testosterone during the neonatal mini-puberty.

Original languageEnglish (US)
Article number101237
JournalUrology Case Reports
Volume32
DOIs
StatePublished - Sep 2020

Keywords

  • Disorder of sex development
  • GnRH agonist
  • Mini-puberty
  • Mosaicism
  • Testicle
  • Testosterone

ASJC Scopus subject areas

  • Urology

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