Hormonal therapy options for biochemical recurrence of prostate cancer after local therapy

J. W. Moul, B. Thrasher, F. Debruyne, J. Sylvester, W. Fair, David Grignon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Recurrence after local prostate cancer treatment detectable only by a rise in serum prostate specific antigen (PSA) is a very common problem facing clinicians. Given that the majority of these men are relatively young and otherwise healthy, treatment of PSA-only recurrence requires approaches that not only improve survival but also preserve quality of life. For radical prostatectomy patients, a PSA-only recurrence is broadly defined as persistent or rising PSA in the postoperative period. For radiation-treated patients, the 1997 American Society for Therapeutic Radiology and Oncology guidelines specify three consecutive elevations of PSA after the post-treatment nadir PSA is achieved. Traditional hormonal therapy is the mainstay of systemic treatment for PSA-only recurrence, although nontraditional approaches such as intermittent and oral-only hormonal therapy are under study.

Original languageEnglish (US)
JournalMolecular Urology
Volume4
Issue number3
StatePublished - 2000
Externally publishedYes

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Prostate-Specific Antigen
Prostatic Neoplasms
Recurrence
Therapeutics
Prostatectomy
Postoperative Period
Quality of Life
Guidelines
Radiation
Survival
Serum

ASJC Scopus subject areas

  • Urology

Cite this

Moul, J. W., Thrasher, B., Debruyne, F., Sylvester, J., Fair, W., & Grignon, D. (2000). Hormonal therapy options for biochemical recurrence of prostate cancer after local therapy. Molecular Urology, 4(3).

Hormonal therapy options for biochemical recurrence of prostate cancer after local therapy. / Moul, J. W.; Thrasher, B.; Debruyne, F.; Sylvester, J.; Fair, W.; Grignon, David.

In: Molecular Urology, Vol. 4, No. 3, 2000.

Research output: Contribution to journalArticle

Moul, JW, Thrasher, B, Debruyne, F, Sylvester, J, Fair, W & Grignon, D 2000, 'Hormonal therapy options for biochemical recurrence of prostate cancer after local therapy', Molecular Urology, vol. 4, no. 3.
Moul, J. W. ; Thrasher, B. ; Debruyne, F. ; Sylvester, J. ; Fair, W. ; Grignon, David. / Hormonal therapy options for biochemical recurrence of prostate cancer after local therapy. In: Molecular Urology. 2000 ; Vol. 4, No. 3.
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