Host-pathogen interplay of Haemophilus ducreyi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Haemophilus ducreyi, the causative agent of the sexually transmitted infection chancroid, is primarily a pathogen of human skin. During infection, H. ducreyi thrives extracellularly in a milieu of professional phagocytes and other antibacterial components of the innate and adaptive immune responses. This review summarizes our understanding of the interplay between this pathogen and its host that leads to development and persistence of disease. RECENT FINDINGS: H. ducreyi expresses key virulence mechanisms to resist host defenses. The secreted LspA proteins are tyrosine-phosphorylated by host kinases, which may contribute to their antiphagocytic effector function. The serum resistance and adherence functions of DsrA map to separate domains of this multifunctional virulence factor. An influx transporter protects H. ducreyi from killing by the antimicrobial peptide LL37. Regulatory genes have been identified that may coordinate virulence factor expression during disease. Dendritic cells and natural killer cells respond to H. ducreyi and may be involved in determining the differential outcomes of infection observed in humans. SUMMARY: A human model of H. ducreyi infection has provided insights into virulence mechanisms that allow this human-specific pathogen to survive immune pressures. Components of the human innate immune system may also determine the ultimate fate of H. ducreyi infection by driving either clearance of the organism or an ineffective response that allows disease progression.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalCurrent Opinion in Infectious Diseases
Volume23
Issue number1
DOIs
StatePublished - Feb 2010

Fingerprint

Haemophilus ducreyi
Haemophilus Infections
Virulence Factors
Virulence
Chancroid
Adaptive Immunity
Regulator Genes
Phagocytes
Sexually Transmitted Diseases
Infection
Innate Immunity
Natural Killer Cells
Dendritic Cells
Tyrosine
Disease Progression
Immune System
Phosphotransferases
Pressure
Skin
Peptides

Keywords

  • Chancroid
  • Differential host susceptibility
  • Haemophilus ducreyi
  • Human model
  • Immunopathogenesis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Host-pathogen interplay of Haemophilus ducreyi. / Janowicz, Diane; Li, Wei; Bauer, Margaret.

In: Current Opinion in Infectious Diseases, Vol. 23, No. 1, 02.2010, p. 64-69.

Research output: Contribution to journalArticle

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