Host risk factors for the development of multiple non-melanoma skin cancers

A. A. Qureshi, E. X. Wei-Passanese, T. Li, Jiali Han

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Non-melanoma skin cancer (NMSC) is the most common cancer in the US, and having multiple lesions conveys substantial cost and morbidity for the individual involved. Although there are data available on risk factors for NMSC, there are currently few studies that identify specific risk factors for development of multiple NMSCs. We evaluated host risk factors for multiple NMSCs among men (Health Professionals Follow-up Study) and women (Nurses' Health Study). Compared with individuals with a single NMSC, having greater number of sunburns was a risk factor for developing ≥2 NMSCs [≥10 sunburns, cumulative relative risk (RR) = 1.21, 95% confidence interval (CI): 1.07-1.36] and a higher risk of developing ≥11 NMSCs (≥10 sunburns, RR = 2.33, 95% CI: 1.57-3.46). Inability-to-tan was associated with risk of developing ≥2 NMSCs (cumulative RR = 1.29, 95% CI: 1.18-1.40) and a higher risk of developing ≥11 NMSCs (RR = 1.91, 95% CI: 1.50-2.43). Men had an increased risk of developing ≥2 NMSCs (cumulative RR = 1.53, 95% CI: 1.40-1.66). Risk of developing 2-4, 5-10 and ≥11 NMSCs increased with age. Other risk factors for developing ≥2 NMSCs included red natural hair colour (cumulative RR = 1.23, 95% CI: 1.07-1.42), family history of melanoma (cumulative RR = 1.15, 95% CI: 1.03-1.28), and having ≥6 nevi on the left arm (cumulative RR = 1.22, 95% CI: 1.07-1.40). In conclusion, physicians caring for individuals with incident NMSCs may consider paying special attention to those at highest risk for developing additional tumours, especially males and those with a history of ≥10 lifetime sunburns, by performing routine full skin examinations and counselling for aggressive photoprotection.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalJournal of the European Academy of Dermatology and Venereology
Volume27
Issue number5
DOIs
StatePublished - May 1 2013
Externally publishedYes

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Skin Neoplasms
Confidence Intervals
Sunburn
Hair Color
Men's Health
Nevus
Women's Health
Counseling
Melanoma
Neoplasms

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Host risk factors for the development of multiple non-melanoma skin cancers. / Qureshi, A. A.; Wei-Passanese, E. X.; Li, T.; Han, Jiali.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 27, No. 5, 01.05.2013, p. 565-570.

Research output: Contribution to journalArticle

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abstract = "Non-melanoma skin cancer (NMSC) is the most common cancer in the US, and having multiple lesions conveys substantial cost and morbidity for the individual involved. Although there are data available on risk factors for NMSC, there are currently few studies that identify specific risk factors for development of multiple NMSCs. We evaluated host risk factors for multiple NMSCs among men (Health Professionals Follow-up Study) and women (Nurses' Health Study). Compared with individuals with a single NMSC, having greater number of sunburns was a risk factor for developing ≥2 NMSCs [≥10 sunburns, cumulative relative risk (RR) = 1.21, 95{\%} confidence interval (CI): 1.07-1.36] and a higher risk of developing ≥11 NMSCs (≥10 sunburns, RR = 2.33, 95{\%} CI: 1.57-3.46). Inability-to-tan was associated with risk of developing ≥2 NMSCs (cumulative RR = 1.29, 95{\%} CI: 1.18-1.40) and a higher risk of developing ≥11 NMSCs (RR = 1.91, 95{\%} CI: 1.50-2.43). Men had an increased risk of developing ≥2 NMSCs (cumulative RR = 1.53, 95{\%} CI: 1.40-1.66). Risk of developing 2-4, 5-10 and ≥11 NMSCs increased with age. Other risk factors for developing ≥2 NMSCs included red natural hair colour (cumulative RR = 1.23, 95{\%} CI: 1.07-1.42), family history of melanoma (cumulative RR = 1.15, 95{\%} CI: 1.03-1.28), and having ≥6 nevi on the left arm (cumulative RR = 1.22, 95{\%} CI: 1.07-1.40). In conclusion, physicians caring for individuals with incident NMSCs may consider paying special attention to those at highest risk for developing additional tumours, especially males and those with a history of ≥10 lifetime sunburns, by performing routine full skin examinations and counselling for aggressive photoprotection.",
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