How accurately does prostate biopsy gleason score predict pathologic findings and disease free survival?

Vivek Narain, Fernando J. Bianco, David J. Grignon, Wael A. Sakr, J. Edson Pontes, David P. Wood

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

OBJECTIVE. Due to the significant impact on prognosis by subgrouping of prostatectomy Gleason scores <7, 7, and >7, we undertook this study to answer whether the biopsy Gleason score was as predictive of disease free survival and assess the correlation with the prostatectomy Gleason score in a modern prostatectomy series. METHODS. An analysis of 1,031 patients who underwent radical prostatectomy for clinically localized prostate cancer was performed. All data was prospectively collected. The Gleason score was categorized into 3 different groups (<7, 7, and >7) for biopsy and prostatectomy specimens. Disease free survival was then analyzed for each group. Discrepancies between scores and outcomes were evaluated. RESULTS. Accurate correlation was noted in 54.8, 66.8, and 47.4% of Gleason scores <7, 7, and >7, respectively. Overall accuracy was 58.3%. Both, biopsy and prostatectomy Gleason score correlated significantly with disease free survival (P=0.001), furthermore the classification (Gleason scores <7, 7 and >7) was highly significant (P=0.001). Patients with prostatectomy Gleason <7 tumors had significant survival advantage over those with biopsy Gleason <7, (P=0.001). However, disease free survival was superior for patients with biopsy Gleason >7 than those with prostatectomy Gleason >7, (P=0.02). The overall disease free survival was similar among the patients with Gleason score of 7 (P=0.12). CONCLUSIONS. It appears that biopsy Gleason score, although oftentimes not correlating strongly with the prostatectomy Gleason score, is an important prognostic factor in prostate cancer. There are significant differences in disease free survival between biopsy and prostatectomy Gleason score categories.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalProstate
Volume49
Issue number3
DOIs
StatePublished - Nov 26 2001

Fingerprint

Neoplasm Grading
Prostatectomy
Disease-Free Survival
Prostate
Biopsy
Prostatic Neoplasms

Keywords

  • Biopsy
  • Gleason score
  • Prostate cancer
  • Prostatectomy

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Narain, V., Bianco, F. J., Grignon, D. J., Sakr, W. A., Edson Pontes, J., & Wood, D. P. (2001). How accurately does prostate biopsy gleason score predict pathologic findings and disease free survival? Prostate, 49(3), 185-190. https://doi.org/10.1002/pros.1133

How accurately does prostate biopsy gleason score predict pathologic findings and disease free survival? / Narain, Vivek; Bianco, Fernando J.; Grignon, David J.; Sakr, Wael A.; Edson Pontes, J.; Wood, David P.

In: Prostate, Vol. 49, No. 3, 26.11.2001, p. 185-190.

Research output: Contribution to journalArticle

Narain, V, Bianco, FJ, Grignon, DJ, Sakr, WA, Edson Pontes, J & Wood, DP 2001, 'How accurately does prostate biopsy gleason score predict pathologic findings and disease free survival?', Prostate, vol. 49, no. 3, pp. 185-190. https://doi.org/10.1002/pros.1133
Narain V, Bianco FJ, Grignon DJ, Sakr WA, Edson Pontes J, Wood DP. How accurately does prostate biopsy gleason score predict pathologic findings and disease free survival? Prostate. 2001 Nov 26;49(3):185-190. https://doi.org/10.1002/pros.1133
Narain, Vivek ; Bianco, Fernando J. ; Grignon, David J. ; Sakr, Wael A. ; Edson Pontes, J. ; Wood, David P. / How accurately does prostate biopsy gleason score predict pathologic findings and disease free survival?. In: Prostate. 2001 ; Vol. 49, No. 3. pp. 185-190.
@article{a6c5e5ce1e474fbbb7f302ccfb5a8212,
title = "How accurately does prostate biopsy gleason score predict pathologic findings and disease free survival?",
abstract = "OBJECTIVE. Due to the significant impact on prognosis by subgrouping of prostatectomy Gleason scores 7, we undertook this study to answer whether the biopsy Gleason score was as predictive of disease free survival and assess the correlation with the prostatectomy Gleason score in a modern prostatectomy series. METHODS. An analysis of 1,031 patients who underwent radical prostatectomy for clinically localized prostate cancer was performed. All data was prospectively collected. The Gleason score was categorized into 3 different groups (7) for biopsy and prostatectomy specimens. Disease free survival was then analyzed for each group. Discrepancies between scores and outcomes were evaluated. RESULTS. Accurate correlation was noted in 54.8, 66.8, and 47.4{\%} of Gleason scores 7, respectively. Overall accuracy was 58.3{\%}. Both, biopsy and prostatectomy Gleason score correlated significantly with disease free survival (P=0.001), furthermore the classification (Gleason scores 7) was highly significant (P=0.001). Patients with prostatectomy Gleason 7 than those with prostatectomy Gleason >7, (P=0.02). The overall disease free survival was similar among the patients with Gleason score of 7 (P=0.12). CONCLUSIONS. It appears that biopsy Gleason score, although oftentimes not correlating strongly with the prostatectomy Gleason score, is an important prognostic factor in prostate cancer. There are significant differences in disease free survival between biopsy and prostatectomy Gleason score categories.",
keywords = "Biopsy, Gleason score, Prostate cancer, Prostatectomy",
author = "Vivek Narain and Bianco, {Fernando J.} and David Grignon and Sakr, {Wael A.} and {Edson Pontes}, J. and Wood, {David P.}",
year = "2001",
doi = "10.1002/pros.1133",
language = "English (US)",
volume = "49",
pages = "185--190",
journal = "Prostate",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - How accurately does prostate biopsy gleason score predict pathologic findings and disease free survival?

AU - Narain, Vivek

AU - Bianco, Fernando J.

AU - Grignon, David J.

AU - Sakr, Wael A.

AU - Edson Pontes, J.

AU - Wood, David P.

PY - 2001/11/26

Y1 - 2001/11/26

N2 - OBJECTIVE. Due to the significant impact on prognosis by subgrouping of prostatectomy Gleason scores <7, 7, and >7, we undertook this study to answer whether the biopsy Gleason score was as predictive of disease free survival and assess the correlation with the prostatectomy Gleason score in a modern prostatectomy series. METHODS. An analysis of 1,031 patients who underwent radical prostatectomy for clinically localized prostate cancer was performed. All data was prospectively collected. The Gleason score was categorized into 3 different groups (<7, 7, and >7) for biopsy and prostatectomy specimens. Disease free survival was then analyzed for each group. Discrepancies between scores and outcomes were evaluated. RESULTS. Accurate correlation was noted in 54.8, 66.8, and 47.4% of Gleason scores <7, 7, and >7, respectively. Overall accuracy was 58.3%. Both, biopsy and prostatectomy Gleason score correlated significantly with disease free survival (P=0.001), furthermore the classification (Gleason scores <7, 7 and >7) was highly significant (P=0.001). Patients with prostatectomy Gleason <7 tumors had significant survival advantage over those with biopsy Gleason <7, (P=0.001). However, disease free survival was superior for patients with biopsy Gleason >7 than those with prostatectomy Gleason >7, (P=0.02). The overall disease free survival was similar among the patients with Gleason score of 7 (P=0.12). CONCLUSIONS. It appears that biopsy Gleason score, although oftentimes not correlating strongly with the prostatectomy Gleason score, is an important prognostic factor in prostate cancer. There are significant differences in disease free survival between biopsy and prostatectomy Gleason score categories.

AB - OBJECTIVE. Due to the significant impact on prognosis by subgrouping of prostatectomy Gleason scores <7, 7, and >7, we undertook this study to answer whether the biopsy Gleason score was as predictive of disease free survival and assess the correlation with the prostatectomy Gleason score in a modern prostatectomy series. METHODS. An analysis of 1,031 patients who underwent radical prostatectomy for clinically localized prostate cancer was performed. All data was prospectively collected. The Gleason score was categorized into 3 different groups (<7, 7, and >7) for biopsy and prostatectomy specimens. Disease free survival was then analyzed for each group. Discrepancies between scores and outcomes were evaluated. RESULTS. Accurate correlation was noted in 54.8, 66.8, and 47.4% of Gleason scores <7, 7, and >7, respectively. Overall accuracy was 58.3%. Both, biopsy and prostatectomy Gleason score correlated significantly with disease free survival (P=0.001), furthermore the classification (Gleason scores <7, 7 and >7) was highly significant (P=0.001). Patients with prostatectomy Gleason <7 tumors had significant survival advantage over those with biopsy Gleason <7, (P=0.001). However, disease free survival was superior for patients with biopsy Gleason >7 than those with prostatectomy Gleason >7, (P=0.02). The overall disease free survival was similar among the patients with Gleason score of 7 (P=0.12). CONCLUSIONS. It appears that biopsy Gleason score, although oftentimes not correlating strongly with the prostatectomy Gleason score, is an important prognostic factor in prostate cancer. There are significant differences in disease free survival between biopsy and prostatectomy Gleason score categories.

KW - Biopsy

KW - Gleason score

KW - Prostate cancer

KW - Prostatectomy

UR - http://www.scopus.com/inward/record.url?scp=0035157532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035157532&partnerID=8YFLogxK

U2 - 10.1002/pros.1133

DO - 10.1002/pros.1133

M3 - Article

C2 - 11746263

AN - SCOPUS:0035157532

VL - 49

SP - 185

EP - 190

JO - Prostate

JF - Prostate

SN - 0270-4137

IS - 3

ER -