How do tumours adapt to nutrient stress

Ronald Wek, Kirk A. Staschke

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Reduced blood flow contributes to tumour hypoxia and nutrient deprivation forcing cancer cells to adapt to ensure survival. In this issue of The EMBO Journal, Ye et al show that a stress response pathway including the eIF2 kinase GCN2 and its downstream target, the transcriptional activator ATF4, is critical for proliferation and survival of tumour cells after starvation for amino acids or glucose and is essential for growth in vivo in a xenograft model. This study provides new mechanistic insight into how tumour cells sense and adapt to nutrient restriction and suggests new approaches for cancer chemotherapy.

Original languageEnglish
Pages (from-to)1946-1947
Number of pages2
JournalEMBO Journal
Volume29
Issue number12
DOIs
StatePublished - Jun 16 2010

Fingerprint

Nutrients
Tumors
Cells
Food
Neoplasms
Chemotherapy
Heterografts
Blood
Phosphotransferases
Starvation
Amino Acids
Glucose
Cell Survival
Drug Therapy
Growth

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

How do tumours adapt to nutrient stress. / Wek, Ronald; Staschke, Kirk A.

In: EMBO Journal, Vol. 29, No. 12, 16.06.2010, p. 1946-1947.

Research output: Contribution to journalArticle

Wek, Ronald ; Staschke, Kirk A. / How do tumours adapt to nutrient stress. In: EMBO Journal. 2010 ; Vol. 29, No. 12. pp. 1946-1947.
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