How many lymph nodes properly stage a periampullary malignancy?

Juan C. Gutierrez, Dido Franceschi, Leonidas Koniaris

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The impact of lymphadenectomy in prognosis and staging in periampullary malignancies remains largely undefined. We examined all pancreaticoduodenectomies for periampullary carcinomas in the SEER cancer registry from 1993 through 2003. Overall, 5465 pancreaticoduodenectomies for nonmetastatic periampullary carcinomas were identified. The cohort was comprised of 62.5% pancreatic, 18.9% ampullary, 11.6% distal bile duct, and 7.0% duodenal cancers. A linear association between the number of lymph nodes (LNs) examined and overall survival was observed overall and for pancreas and ampullary cancers for node-negative (N0) disease. Median survival for all patients with localized, N0 disease improved from 24 to 31 months, with sampling of a minimum of 10 LNs, whereas 2 and 5-year survival improved from 52 and 29%, with

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume12
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Pancreaticoduodenectomy
Lymph Nodes
Survival
Duodenal Neoplasms
Carcinoma
Neoplasms
Bile Ducts
Lymph Node Excision
Pancreatic Neoplasms
Registries

Keywords

  • Lymph node
  • Outcomes
  • Periampullary
  • SEER
  • Whipple

ASJC Scopus subject areas

  • Surgery

Cite this

How many lymph nodes properly stage a periampullary malignancy? / Gutierrez, Juan C.; Franceschi, Dido; Koniaris, Leonidas.

In: Journal of Gastrointestinal Surgery, Vol. 12, No. 1, 01.2008, p. 77-85.

Research output: Contribution to journalArticle

Gutierrez, Juan C. ; Franceschi, Dido ; Koniaris, Leonidas. / How many lymph nodes properly stage a periampullary malignancy?. In: Journal of Gastrointestinal Surgery. 2008 ; Vol. 12, No. 1. pp. 77-85.
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