How the innate immune system senses trouble and causes trouble

Takashi Hato, Pierre C. Dagher

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The innate immune system is the first line of defense in response to nonself and danger signals from microbial invasion or tissue injury. It is increasingly recognized that each organ uses unique sets of cells and molecules that orchestrate regional innate immunity. The cells that execute the task of innate immunity are many and consist of not only “professional” immune cells but also nonimmune cells, such as renal epithelial cells. Despite a high level of sophistication, deregulated innate immunity is common and contributes to a wide range of renal diseases, such as sepsis-induced kidney injury, GN, and allograft dysfunction. This review discusses how the innate immune system recognizes and responds to nonself and danger signals. In particular, the roles of renal epithelial cells that make them an integral part of the innate immune apparatus of the kidney are highlighted.

Original languageEnglish (US)
Pages (from-to)1459-1469
Number of pages11
JournalClinical Journal of the American Society of Nephrology
Volume10
Issue number8
DOIs
StatePublished - Aug 7 2015

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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