Human β-galactoside α-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity

Su Huang, Travis W. Day, Mi Ran Choi, Ahmad R. Safa

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Taxol triggers apoptosis in a variety of cancer cells, but it also upregulates cytoprotective proteins and/or pathways that compromise its therapeutic efficacy. In this report, we found that Taxol treatment resulted in caspase-8-dependent apoptosis in SKOV3 human ovarian cancer cells. Moreover, Taxol-induced apoptosis was associated with caspase-3 activation. Interestingly, Taxol treatment upregulated α-2,3-sialyltransferase (ST3Gal III) expression and forced expression of ST3Gal III attenuated Taxol-induced apoptosis. Furthermore, ST3Gal III overexpression inhibited Taxol-triggered caspase-8 activation, indicating that ST3Gal III upregulation produces cellular resistance to Taxol and hence reduces the efficacy of Taxol therapy.

Original languageEnglish (US)
Pages (from-to)81-88
Number of pages8
JournalMolecular and Cellular Biochemistry
Volume331
Issue number1-2
DOIs
StatePublished - 2009

Keywords

  • Apoptosis
  • Caspase-8
  • Ovarian cancer
  • Sialylation
  • Sialyltransferases
  • ST3Gal III
  • Taxol

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Human β-galactoside α-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity'. Together they form a unique fingerprint.

  • Cite this