Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23

Hiroyuki Nomoto, Toshitaka Oohashi, Satoshi Hirakawa, Yasuyoshi Ueki, Hiroshi Ohtsuki, Yoshifumi Ninomiya

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We herein determined by fluorescence in situ hybridization the chromosomal localization of 2 human genes, BRAL1 and BCAN, both of which belong to the link-module superfamily, i.e. to the same band of chromosome 1q21-23. Further analysis of the genomic organization of BRAL1 and BCAN revealed that the BRAL1 gene was located 20-kb upstream of the BCAN start site. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the BCAN gene. High heterozygosity (0.79) makes this polymorphism a useful marker in the study of genetic disorders. Knowledge of the structure of the genes and the marker provides essential information for further analysis of the gene locus at chromosome 1q21-23.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalActa Medica Okayama
Volume56
Issue number1
StatePublished - Dec 1 2002
Externally publishedYes

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Chromosomes
Genes
Dinucleotide Repeats
Inborn Genetic Diseases
Polymorphism
Fluorescence In Situ Hybridization
Clone Cells
Fluorescence

Keywords

  • BCAN
  • BRAL1
  • FISH
  • Polymorphic marker
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. / Nomoto, Hiroyuki; Oohashi, Toshitaka; Hirakawa, Satoshi; Ueki, Yasuyoshi; Ohtsuki, Hiroshi; Ninomiya, Yoshifumi.

In: Acta Medica Okayama, Vol. 56, No. 1, 01.12.2002, p. 25-29.

Research output: Contribution to journalArticle

Nomoto, H, Oohashi, T, Hirakawa, S, Ueki, Y, Ohtsuki, H & Ninomiya, Y 2002, 'Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23', Acta Medica Okayama, vol. 56, no. 1, pp. 25-29.
Nomoto, Hiroyuki ; Oohashi, Toshitaka ; Hirakawa, Satoshi ; Ueki, Yasuyoshi ; Ohtsuki, Hiroshi ; Ninomiya, Yoshifumi. / Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. In: Acta Medica Okayama. 2002 ; Vol. 56, No. 1. pp. 25-29.
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