Human cystic kidney diseases: epithelial hyperplasia in the pathogenesis of cysts and tumors

Jay Bernstein, Andrew Evan, Kenneth D. Gardner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Several examples of human renal cystic disease are associated with tubular epithelial hyperplasia. Micropapillary hyperplasia occurs in autosomal dominant polycystic kidney disease, in localized cystic disease, and in acquired cystic disease; neoplastic or severely dysplastic epithelial hyperplasia occurs in von Hippel-Lindau disease; a histopathologically distinctive epithelial hyperplasia occurs in tuberous sclerosis. In all of these conditions the epithelial hyperplasia appears to be responsible for cyst formation by causing tubular or ductal luminal obstruction, and in all of these conditions, save localized cystic disease (a rare condition with very few reported cases), epithelial hyperplasia imposes an increased risk of malignancy. The risk seems to be highest in patients under treatment with long-term hemodialysis for end-stage kidney disease. Some of these diseases may share common features, but it appears likely that the histopathological differences reflect different features converging on a common result.

Original languageEnglish
Pages (from-to)393-396
Number of pages4
JournalPediatric Nephrology
Volume1
Issue number3
DOIs
StatePublished - Sep 1987

Fingerprint

Cystic Kidney Diseases
Hyperplasia
Cysts
Neoplasms
von Hippel-Lindau Disease
Autosomal Dominant Polycystic Kidney
Tuberous Sclerosis
Rare Diseases
Chronic Kidney Failure
Renal Dialysis

Keywords

  • Acquired renal cystic disease
  • Polycystic kidney disease
  • Renal carcinoma
  • Tuberous sclerosis
  • von Hippel-Lindau disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Human cystic kidney diseases : epithelial hyperplasia in the pathogenesis of cysts and tumors. / Bernstein, Jay; Evan, Andrew; Gardner, Kenneth D.

In: Pediatric Nephrology, Vol. 1, No. 3, 09.1987, p. 393-396.

Research output: Contribution to journalArticle

@article{0c7ea35f6d6044a4ad7f2321ef6174d6,
title = "Human cystic kidney diseases: epithelial hyperplasia in the pathogenesis of cysts and tumors",
abstract = "Several examples of human renal cystic disease are associated with tubular epithelial hyperplasia. Micropapillary hyperplasia occurs in autosomal dominant polycystic kidney disease, in localized cystic disease, and in acquired cystic disease; neoplastic or severely dysplastic epithelial hyperplasia occurs in von Hippel-Lindau disease; a histopathologically distinctive epithelial hyperplasia occurs in tuberous sclerosis. In all of these conditions the epithelial hyperplasia appears to be responsible for cyst formation by causing tubular or ductal luminal obstruction, and in all of these conditions, save localized cystic disease (a rare condition with very few reported cases), epithelial hyperplasia imposes an increased risk of malignancy. The risk seems to be highest in patients under treatment with long-term hemodialysis for end-stage kidney disease. Some of these diseases may share common features, but it appears likely that the histopathological differences reflect different features converging on a common result.",
keywords = "Acquired renal cystic disease, Polycystic kidney disease, Renal carcinoma, Tuberous sclerosis, von Hippel-Lindau disease",
author = "Jay Bernstein and Andrew Evan and Gardner, {Kenneth D.}",
year = "1987",
month = "9",
doi = "10.1007/BF00849242",
language = "English",
volume = "1",
pages = "393--396",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Human cystic kidney diseases

T2 - epithelial hyperplasia in the pathogenesis of cysts and tumors

AU - Bernstein, Jay

AU - Evan, Andrew

AU - Gardner, Kenneth D.

PY - 1987/9

Y1 - 1987/9

N2 - Several examples of human renal cystic disease are associated with tubular epithelial hyperplasia. Micropapillary hyperplasia occurs in autosomal dominant polycystic kidney disease, in localized cystic disease, and in acquired cystic disease; neoplastic or severely dysplastic epithelial hyperplasia occurs in von Hippel-Lindau disease; a histopathologically distinctive epithelial hyperplasia occurs in tuberous sclerosis. In all of these conditions the epithelial hyperplasia appears to be responsible for cyst formation by causing tubular or ductal luminal obstruction, and in all of these conditions, save localized cystic disease (a rare condition with very few reported cases), epithelial hyperplasia imposes an increased risk of malignancy. The risk seems to be highest in patients under treatment with long-term hemodialysis for end-stage kidney disease. Some of these diseases may share common features, but it appears likely that the histopathological differences reflect different features converging on a common result.

AB - Several examples of human renal cystic disease are associated with tubular epithelial hyperplasia. Micropapillary hyperplasia occurs in autosomal dominant polycystic kidney disease, in localized cystic disease, and in acquired cystic disease; neoplastic or severely dysplastic epithelial hyperplasia occurs in von Hippel-Lindau disease; a histopathologically distinctive epithelial hyperplasia occurs in tuberous sclerosis. In all of these conditions the epithelial hyperplasia appears to be responsible for cyst formation by causing tubular or ductal luminal obstruction, and in all of these conditions, save localized cystic disease (a rare condition with very few reported cases), epithelial hyperplasia imposes an increased risk of malignancy. The risk seems to be highest in patients under treatment with long-term hemodialysis for end-stage kidney disease. Some of these diseases may share common features, but it appears likely that the histopathological differences reflect different features converging on a common result.

KW - Acquired renal cystic disease

KW - Polycystic kidney disease

KW - Renal carcinoma

KW - Tuberous sclerosis

KW - von Hippel-Lindau disease

UR - http://www.scopus.com/inward/record.url?scp=0023580148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023580148&partnerID=8YFLogxK

U2 - 10.1007/BF00849242

DO - 10.1007/BF00849242

M3 - Article

C2 - 3153306

AN - SCOPUS:0023580148

VL - 1

SP - 393

EP - 396

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 3

ER -