Human Exposure to Polychlorinated Biphenyls (PCBs): A Critical Assessment of the Evidence for Adverse Health Effects

G. M. Swanson, H. E. Ratcliffe, L. J. Fischer

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Results from epidemiologic studies involving human exposures to polychlorinated biphenyls (PCBs) are often used to estimate the potential risk or hazard posed by the presence of these chemicals in the workplace or the environment. The use of results and conclusions from individual studies requires an assessment of the scientific quality of the information contained in published reports. The results of a critical review of the scientific literature reported here should be an aid to those who are interested in risk evaluations surrounding exposures to PCBs. There are diverse approaches that one could take to an evaluation of scientific reports of the health hazards of various chemicals. We present one approach to assessing the strengths and weaknesses of studies conducted to understand the potential association between PCB exposure and human health effects. A comprehensive review of the scientific literature involving human exposures to PCBs was performed and each study was evaluated on the basis of a defined set of criteria that were considered standards in epidemiologic research. Two of the 39 occupational studies reviewed provided positive evidence and 3 suggestive evidence for an exposure-related effect, whereas none of the 33 studies where exposure had occurred in the natural environment provided positive or suggestive evidence of an association with adverse effects.

Original languageEnglish (US)
Pages (from-to)136-150
Number of pages15
JournalRegulatory Toxicology and Pharmacology
Volume21
Issue number1
DOIs
StatePublished - Feb 1995
Externally publishedYes

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Polychlorinated Biphenyls
Health
Health hazards
Workplace
Epidemiologic Studies
Hazards
Research

ASJC Scopus subject areas

  • Toxicology

Cite this

Human Exposure to Polychlorinated Biphenyls (PCBs) : A Critical Assessment of the Evidence for Adverse Health Effects. / Swanson, G. M.; Ratcliffe, H. E.; Fischer, L. J.

In: Regulatory Toxicology and Pharmacology, Vol. 21, No. 1, 02.1995, p. 136-150.

Research output: Contribution to journalArticle

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