Human homolog of patched, a candidate gene for the basal cell nevus syndrome

Ronald L. Johnson, Alana L. Rothman, Jingwu Xie, Lisa V. Goodrich, John W. Bare, Jeannette M. Bonifas, Anthony G. Quinn, Richard M. Myers, David R. Cox, Ervin H. Epstein, Matthew P. Scott

Research output: Contribution to journalArticle

1495 Citations (Scopus)

Abstract

The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the most common human cancer. Heritable mutations in BCNS patients and a somatic mutation in a sporadic BCC were identified in a human homolog of the Drosophila patched (ptc) gene. The ptc gene encodes a transmembrane protein that in Drosophila acts in opposition to the Hedgehog signaling protein, controlling cell fates, patterning, and growth in numerous tissues. The human PTC gene appears to be crucial for proper embryonic development and for tumor suppression.

Original languageEnglish (US)
Pages (from-to)1668-1671
Number of pages4
JournalScience
Volume272
Issue number5268
StatePublished - Jun 14 1996
Externally publishedYes

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Basal Cell Nevus Syndrome
Basal Cell Carcinoma
Hedgehog Proteins
Genes
Neoplasms
Mutation
Factor IX
Drosophila
Embryonic Development
Growth

ASJC Scopus subject areas

  • General

Cite this

Johnson, R. L., Rothman, A. L., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., ... Scott, M. P. (1996). Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science, 272(5268), 1668-1671.

Human homolog of patched, a candidate gene for the basal cell nevus syndrome. / Johnson, Ronald L.; Rothman, Alana L.; Xie, Jingwu; Goodrich, Lisa V.; Bare, John W.; Bonifas, Jeannette M.; Quinn, Anthony G.; Myers, Richard M.; Cox, David R.; Epstein, Ervin H.; Scott, Matthew P.

In: Science, Vol. 272, No. 5268, 14.06.1996, p. 1668-1671.

Research output: Contribution to journalArticle

Johnson, RL, Rothman, AL, Xie, J, Goodrich, LV, Bare, JW, Bonifas, JM, Quinn, AG, Myers, RM, Cox, DR, Epstein, EH & Scott, MP 1996, 'Human homolog of patched, a candidate gene for the basal cell nevus syndrome', Science, vol. 272, no. 5268, pp. 1668-1671.
Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 1996 Jun 14;272(5268):1668-1671.
Johnson, Ronald L. ; Rothman, Alana L. ; Xie, Jingwu ; Goodrich, Lisa V. ; Bare, John W. ; Bonifas, Jeannette M. ; Quinn, Anthony G. ; Myers, Richard M. ; Cox, David R. ; Epstein, Ervin H. ; Scott, Matthew P. / Human homolog of patched, a candidate gene for the basal cell nevus syndrome. In: Science. 1996 ; Vol. 272, No. 5268. pp. 1668-1671.
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