Human immunodeficiency virus and leprosy coinfection: Challenges in resource-limited setups

Charles M. Kwobah, Kara Wools-Kaloustian, Jane N. Gitau, Abraham M. Siika

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Mycobacteria leprae(leprosy) and HIV coinfection are rare in Kenya. This is likely related to the low prevalence (1 per 10,000 of population) of leprosy. Because leprosy is no longer a public health challenge there is generally a low index of suspicion amongst clinicians for its diagnosis. Management of a HIV-1-leprosy-coinfected individual in a resource-constrained setting is challenging. Some of these challenges include difficulties in establishing a diagnosis of leprosy; the high pill burden of cotreatment with both antileprosy and antiretroviral drugs (ARVs); medications' side effects; drug interactions; scarcity of drug choices for both diseases. This challenge is more profound when managing a patient who requires second-line antiretroviral therapy (ART). We present an adult male patient coinfected with HIV and leprosy, who failed first-line antiretroviral therapy (ART) and required second-line treatment. Due to limited choices in antileprosy drugs available, the patient received monthly rifampicin and daily lopinavir-/ritonavir-based antileprosy and ART regimens, respectively. Six months into his cotreatment, he seemed to have adequate virological control. This case report highlights the challenges of managing such a patient.

Original languageEnglish (US)
Article number698513
JournalCase Reports in Medicine
Volume2012
DOIs
StatePublished - 2012

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Leprosy
Coinfection
HIV
Pharmaceutical Preparations
Lopinavir
Mycobacterium leprae
Ritonavir
Kenya
Therapeutics
Rifampin
Drug Interactions
HIV-1
Public Health
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Human immunodeficiency virus and leprosy coinfection : Challenges in resource-limited setups. / Kwobah, Charles M.; Wools-Kaloustian, Kara; Gitau, Jane N.; Siika, Abraham M.

In: Case Reports in Medicine, Vol. 2012, 698513, 2012.

Research output: Contribution to journalArticle

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abstract = "Mycobacteria leprae(leprosy) and HIV coinfection are rare in Kenya. This is likely related to the low prevalence (1 per 10,000 of population) of leprosy. Because leprosy is no longer a public health challenge there is generally a low index of suspicion amongst clinicians for its diagnosis. Management of a HIV-1-leprosy-coinfected individual in a resource-constrained setting is challenging. Some of these challenges include difficulties in establishing a diagnosis of leprosy; the high pill burden of cotreatment with both antileprosy and antiretroviral drugs (ARVs); medications' side effects; drug interactions; scarcity of drug choices for both diseases. This challenge is more profound when managing a patient who requires second-line antiretroviral therapy (ART). We present an adult male patient coinfected with HIV and leprosy, who failed first-line antiretroviral therapy (ART) and required second-line treatment. Due to limited choices in antileprosy drugs available, the patient received monthly rifampicin and daily lopinavir-/ritonavir-based antileprosy and ART regimens, respectively. Six months into his cotreatment, he seemed to have adequate virological control. This case report highlights the challenges of managing such a patient.",
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