Human papillomavirus deoxyribonucleic acid in lesions of the female genital tract: Evidence for type 6/11 in squamous carcinoma of the vulva

Gregory P. Sutton, Frederick Stehman, Clarence E. Ehrlich, Ann Roman

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Tissue specimens from 51 patients with genital condyloma acuminata or invasive cervical or vulvar carcinomas were analyzed for the presence of human papillomavirus deoxyribonucleic acid (DNA) using the dot blot technique. Of ten condylomas, 80% contained DNA related to human papillomavirus 6 or 11. Sixty percent had evidence of DNA related to human papillomavirus 16, and 30% contained DNA related to human papillomavirus 18. Of 24 squamous cervical carcinomas, 58% had human papillomavirus type 16-related DNA, 33% had type 6 or 11-related DNA, and 4% had type 18-related DNA. Nine primary or recurrent vulvar carcinomas were analyzed. Seventy-eight percent contained human papillomavirus type 6 or 11-related DNA, 33% type 16-related DNA, and 22% type 18-related DNA. Whereas invasive cervical carcinomas predominantly contained DNA related to human papillomavirus 16 or 18, invasive vulvar carcinomas predominantly contained DNA related to types 6 or 11. Thus, human papillomavirus type alone cannot distinguish benign from malignant epithelial disease in the female genital tract.

Original languageEnglish
Pages (from-to)564-568
Number of pages5
JournalObstetrics and Gynecology
Volume70
Issue number4
StatePublished - 1987

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Vulva
Squamous Cell Carcinoma
DNA
Human papillomavirus 16
Human papillomavirus 11
Human papillomavirus 6
Carcinoma
Human papillomavirus 18
Female Genital Diseases
Condylomata Acuminata

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Human papillomavirus deoxyribonucleic acid in lesions of the female genital tract : Evidence for type 6/11 in squamous carcinoma of the vulva. / Sutton, Gregory P.; Stehman, Frederick; Ehrlich, Clarence E.; Roman, Ann.

In: Obstetrics and Gynecology, Vol. 70, No. 4, 1987, p. 564-568.

Research output: Contribution to journalArticle

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