Human papillomavirus (HPV)-induced neoplasia in the urinary bladder: A missing link?

Riley E. Alexander, Lisha Wang, Antonio Lopez-Beltran, Robert E. Emerson, Rodolfo Montironi, Jose A. Pedrosa, Hristos Z. Kaimakliotis, Michael O. Koch, Liang Cheng

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


The discovery that the role human papillomavirus (HPV) plays in the induction of human cancer represents an important achievement in oncologic research. It has taken on even greater importance since the development of vaccines, which promise the hope of preventing these cancers from ever occurring. Because of these important implications, many have attempted to determine a possible role for the virus in cancers of the urinary bladder-an organ in close anatomic proximity to the primary sites of HPV-induced neoplasia and one which already has an established oncogenic infectious agent in Schistosoma haematobium. Here we review the current literature exploring this possible role in the most common subtype of cancer of the urinary bladder, urothelial carcinoma, and two much more rare histologic subtypes that have well established roles for HPVinduced neoplasia in other anatomic sites-squamous cell carcinoma and adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)595-600
Number of pages6
JournalHistology and Histopathology
Issue number6
StatePublished - Jun 2016


  • Biomarker
  • Human papillomavirus (HPV)
  • Squamous cell carcinoma
  • Transitional cell (urothelial) carcinoma
  • Urinary bladder
  • Viral carcinogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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