Human papillomavirus is not an etiologic agent of urothelial inverted papillomas

Riley E. Alexander, Darrell Davidson, Antonio Lopez-Beltran, Rodolfo Montironi, Gregory T. Maclennan, Eva Compérat, Muhammad Idrees, Robert Emerson, Liang Cheng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Inverted papilloma of the urinary bladder is rare, accounting for <1% of all bladder neoplasms. Although there is general consensus that inverted papilloma is benign in nature, little is known about its pathogenesis. Some have suggested that human papillomavirus (HPV) plays an etiologic role in the development of this neoplasm. These claims have not been adequately substantiated, and there is controversy as to the role of HPV in other urinary bladder neoplasms as well. To further investigate a possible etiologic role of HPV in urothelial neoplasia, we evaluated 27 inverted papillomas of the urinary bladder for the presence of HPV. Both immunohistochemical and in situ hybridization (ISH) studies for HPV and immunohistochemical analysis for p16, a surrogate marker for HPV infection, were used to assess HPV infection status. In the urinary bladder inverted papillomas of these 27 patients (age range, 35 to 78 y; M:F ratio, 11:1), no HPV was detected by HPV immunohistochemistry or by ISH. Immunoreactivity to p16 was detected in 11/27 (41%) of the cases. Expression of p16 is seen inconsistently within these neoplasms and does not correlate with the presence of HPV antigens or genes by immunohistochemistry or ISH, respectively. Therefore, p16 is not a reliable surrogate marker for HPV infection in urothelial inverted papilloma. Our findings indicate the absence of HPV in urothelial inverted papillomas. HPV testing should not be used as a diagnostic adjunct for inverted papilloma cases.

Original languageEnglish
Pages (from-to)1223-1228
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume37
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Inverted Papilloma
Papillomavirus Infections
In Situ Hybridization
Urinary Bladder
Urinary Bladder Neoplasms
Biomarkers
Immunohistochemistry
Neoplasms

Keywords

  • carcinogenesis
  • differential diagnosis
  • human papillomavirus (HPV) infection
  • inverted papilloma
  • p16
  • urinary bladder

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Human papillomavirus is not an etiologic agent of urothelial inverted papillomas. / Alexander, Riley E.; Davidson, Darrell; Lopez-Beltran, Antonio; Montironi, Rodolfo; Maclennan, Gregory T.; Compérat, Eva; Idrees, Muhammad; Emerson, Robert; Cheng, Liang.

In: American Journal of Surgical Pathology, Vol. 37, No. 8, 08.2013, p. 1223-1228.

Research output: Contribution to journalArticle

Alexander, Riley E. ; Davidson, Darrell ; Lopez-Beltran, Antonio ; Montironi, Rodolfo ; Maclennan, Gregory T. ; Compérat, Eva ; Idrees, Muhammad ; Emerson, Robert ; Cheng, Liang. / Human papillomavirus is not an etiologic agent of urothelial inverted papillomas. In: American Journal of Surgical Pathology. 2013 ; Vol. 37, No. 8. pp. 1223-1228.
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