Human retinal pigment epithelial cells in the vitreous of the owl monkey

I. Grierson, M. Boulton, P. Hiscott, C. Hitchins, D. Gilbert, D. McLeod

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cultured human retinal pigment epithelium was injected into the vitreous of owl monkeys. The epithelial cells were derived from either a foetal or an adult cell line. The five monkeys which were injected with cultured foetal cells developed substantial vitreal membranes and had retinal detachment by 2 weeks, whereas the five monkeys with cultured adult cells did not develop detachments within the period of investigation, and vitreal membranes were insubstantial. An electron-microscopic, immunohistochemical and autoradiographic study was conducted on these eyes to investigate in detail the behaviour and intraocular effects of the injected cells.

Original languageEnglish (US)
Pages (from-to)491-502
Number of pages12
JournalExperimental Eye Research
Volume43
Issue number4
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Aotidae
Retinal Pigments
Haplorhini
Cultured Cells
Epithelial Cells
Membranes
Retinal Pigment Epithelium
Retinal Detachment
Electrons
Cell Line

Keywords

  • contructile membranes
  • glia
  • retinal detachment
  • retinal pigment epithelium
  • vitreous

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Grierson, I., Boulton, M., Hiscott, P., Hitchins, C., Gilbert, D., & McLeod, D. (1986). Human retinal pigment epithelial cells in the vitreous of the owl monkey. Experimental Eye Research, 43(4), 491-502. https://doi.org/10.1016/S0014-4835(86)80018-5

Human retinal pigment epithelial cells in the vitreous of the owl monkey. / Grierson, I.; Boulton, M.; Hiscott, P.; Hitchins, C.; Gilbert, D.; McLeod, D.

In: Experimental Eye Research, Vol. 43, No. 4, 1986, p. 491-502.

Research output: Contribution to journalArticle

Grierson, I, Boulton, M, Hiscott, P, Hitchins, C, Gilbert, D & McLeod, D 1986, 'Human retinal pigment epithelial cells in the vitreous of the owl monkey', Experimental Eye Research, vol. 43, no. 4, pp. 491-502. https://doi.org/10.1016/S0014-4835(86)80018-5
Grierson, I. ; Boulton, M. ; Hiscott, P. ; Hitchins, C. ; Gilbert, D. ; McLeod, D. / Human retinal pigment epithelial cells in the vitreous of the owl monkey. In: Experimental Eye Research. 1986 ; Vol. 43, No. 4. pp. 491-502.
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