Human retinal pigment epithelial cells in the vitreous of the owl monkey

I. Grierson, M. Boulton, P. Hiscott, C. Hitchins, D. Gilbert, D. McLeod

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Cultured human retinal pigment epithelium was injected into the vitreous of owl monkeys. The epithelial cells were derived from either a foetal or an adult cell line. The five monkeys which were injected with cultured foetal cells developed substantial vitreal membranes and had retinal detachment by 2 weeks, whereas the five monkeys with cultured adult cells did not develop detachments within the period of investigation, and vitreal membranes were insubstantial. An electron-microscopic, immunohistochemical and autoradiographic study was conducted on these eyes to investigate in detail the behaviour and intraocular effects of the injected cells.

Original languageEnglish (US)
Pages (from-to)491-502
Number of pages12
JournalExperimental eye research
Volume43
Issue number4
DOIs
StatePublished - Oct 1986

Keywords

  • contructile membranes
  • glia
  • retinal detachment
  • retinal pigment epithelium
  • vitreous

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Grierson, I., Boulton, M., Hiscott, P., Hitchins, C., Gilbert, D., & McLeod, D. (1986). Human retinal pigment epithelial cells in the vitreous of the owl monkey. Experimental eye research, 43(4), 491-502. https://doi.org/10.1016/S0014-4835(86)80018-5