Human SLC4A11 is a novel NH3/H+ co-transporter

Wenlin Zhang, Diego G. Ogando, Joseph A. Bonanno, Alexander G. Obukhov

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Background: Mutations in SLC4A11 result in corneal endothelial dystrophies; however, the transport characteristics of this membrane protein remain unclear. Results: SLC4A11 showed NH4Cl-dependent currents indicative of a NH3/H+ electrogenic co-transport mode. Conclusion: SLC4A11 is a novel NH3/H+ co-transporter, uncharacteristic of the SLC4 bicarbonate transporter family. Significance: SLC4A11 ammonia transport capacity should be considered along with other NH3 transporters/channels when examining tissue nitrogen homeostasis.

Original languageEnglish (US)
Pages (from-to)16894-16905
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number27
DOIs
StatePublished - Jul 3 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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