Hybrid cytokines as hematopoietic growth factors

Douglas E. Williams, Linda S. Park, Hal E. Broxmeyer, Li Lu

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A large body of in vitro and in vivo data suggests that combinations of cytokines provide the most effective mechanism for stimulating multilineage acceleration of hema‐topoiesis. Creation of a granulocyte‐macrophage colony‐stimulating factor (GM‐CSF)/ interleukin 3 (DL‐3) fusion protein has yielded a single therapeutic which has enhanced biological activity in comparison to the individual cytokines from which it is composed. In vivo studies with this fusion protein (PIXY321) suggest that it may provide a means to accelerate both neutrophil and platelet recovery in clinical settings in which hematopoiesis is suppressed. The biology of PIKY321 and the potential for other fusion proteins is discussed.

Original languageEnglish (US)
Pages (from-to)542-547
Number of pages6
JournalThe International Journal of Cell Cloning
Issue number6
StatePublished - 1991


  • Cytokines
  • Fusion protein
  • Granulocyte‐macrophage colony‐stimulating factor
  • Hematopoiesis
  • Interleukin 3
  • Myelosuppression

ASJC Scopus subject areas

  • Cell Biology

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