Hydrogen Sulfide: A Potential Novel Therapy for the Treatment of Ischemia

Amanda R. Jensen, Natalie A. Drucker, Sina Khaneki, Michael J. Ferkowicz, Mervin Yoder, Eric R. Deleon, Kenneth Olson, Troy A. Markel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hydrogen sulfide (H 2 S) is a novel signaling molecule most recently found to be of fundamental importance in cellular function as a regulator of apoptosis, inflammation, and perfusion. Mechanisms of endogenous H 2 S signaling are poorly understood; however, signal transmission is thought to occur via persulfidation at reactive cysteine residues on proteins. Although much has been discovered about how H 2 S is synthesized in the body, less is known about how it is metabolized. Recent studies have discovered a multitude of different targets for H 2 S therapy, including those related to protein modification, intracellular signaling, and ion channel depolarization. The most difficult part of studying hydrogen sulfide has been finding a way to accurately and reproducibly measure it. The purpose of this review is to: elaborate on the biosynthesis and catabolism of H 2 S in the human body, review current knowledge of the mechanisms of action of this gas in relation to ischemic injury, define strategies for physiological measurement of H 2 S in biological systems, and review potential novel therapies that use H 2 S for treatment.

Original languageEnglish (US)
Pages (from-to)511-524
Number of pages14
JournalShock
Volume48
Issue number5
DOIs
StatePublished - Nov 1 2017

Fingerprint

Hydrogen Sulfide
Intracellular Signaling Peptides and Proteins
Ischemia
Ion Channels
Human Body
Cysteine
Perfusion
Gases
Apoptosis
Inflammation
Wounds and Injuries
Therapeutics
Proteins

Keywords

  • Hydrogen sulfide
  • ischemia
  • NaHS
  • persulfidation
  • polysulfide

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Jensen, A. R., Drucker, N. A., Khaneki, S., Ferkowicz, M. J., Yoder, M., Deleon, E. R., ... Markel, T. A. (2017). Hydrogen Sulfide: A Potential Novel Therapy for the Treatment of Ischemia. Shock, 48(5), 511-524. https://doi.org/10.1097/SHK.0000000000000894

Hydrogen Sulfide : A Potential Novel Therapy for the Treatment of Ischemia. / Jensen, Amanda R.; Drucker, Natalie A.; Khaneki, Sina; Ferkowicz, Michael J.; Yoder, Mervin; Deleon, Eric R.; Olson, Kenneth; Markel, Troy A.

In: Shock, Vol. 48, No. 5, 01.11.2017, p. 511-524.

Research output: Contribution to journalArticle

Jensen, AR, Drucker, NA, Khaneki, S, Ferkowicz, MJ, Yoder, M, Deleon, ER, Olson, K & Markel, TA 2017, 'Hydrogen Sulfide: A Potential Novel Therapy for the Treatment of Ischemia', Shock, vol. 48, no. 5, pp. 511-524. https://doi.org/10.1097/SHK.0000000000000894
Jensen AR, Drucker NA, Khaneki S, Ferkowicz MJ, Yoder M, Deleon ER et al. Hydrogen Sulfide: A Potential Novel Therapy for the Treatment of Ischemia. Shock. 2017 Nov 1;48(5):511-524. https://doi.org/10.1097/SHK.0000000000000894
Jensen, Amanda R. ; Drucker, Natalie A. ; Khaneki, Sina ; Ferkowicz, Michael J. ; Yoder, Mervin ; Deleon, Eric R. ; Olson, Kenneth ; Markel, Troy A. / Hydrogen Sulfide : A Potential Novel Therapy for the Treatment of Ischemia. In: Shock. 2017 ; Vol. 48, No. 5. pp. 511-524.
@article{16993797b09e4caa9a916e5a9c42c951,
title = "Hydrogen Sulfide: A Potential Novel Therapy for the Treatment of Ischemia",
abstract = "Hydrogen sulfide (H 2 S) is a novel signaling molecule most recently found to be of fundamental importance in cellular function as a regulator of apoptosis, inflammation, and perfusion. Mechanisms of endogenous H 2 S signaling are poorly understood; however, signal transmission is thought to occur via persulfidation at reactive cysteine residues on proteins. Although much has been discovered about how H 2 S is synthesized in the body, less is known about how it is metabolized. Recent studies have discovered a multitude of different targets for H 2 S therapy, including those related to protein modification, intracellular signaling, and ion channel depolarization. The most difficult part of studying hydrogen sulfide has been finding a way to accurately and reproducibly measure it. The purpose of this review is to: elaborate on the biosynthesis and catabolism of H 2 S in the human body, review current knowledge of the mechanisms of action of this gas in relation to ischemic injury, define strategies for physiological measurement of H 2 S in biological systems, and review potential novel therapies that use H 2 S for treatment.",
keywords = "Hydrogen sulfide, ischemia, NaHS, persulfidation, polysulfide",
author = "Jensen, {Amanda R.} and Drucker, {Natalie A.} and Sina Khaneki and Ferkowicz, {Michael J.} and Mervin Yoder and Deleon, {Eric R.} and Kenneth Olson and Markel, {Troy A.}",
year = "2017",
month = "11",
day = "1",
doi = "10.1097/SHK.0000000000000894",
language = "English (US)",
volume = "48",
pages = "511--524",
journal = "Shock",
issn = "1073-2322",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Hydrogen Sulfide

T2 - A Potential Novel Therapy for the Treatment of Ischemia

AU - Jensen, Amanda R.

AU - Drucker, Natalie A.

AU - Khaneki, Sina

AU - Ferkowicz, Michael J.

AU - Yoder, Mervin

AU - Deleon, Eric R.

AU - Olson, Kenneth

AU - Markel, Troy A.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Hydrogen sulfide (H 2 S) is a novel signaling molecule most recently found to be of fundamental importance in cellular function as a regulator of apoptosis, inflammation, and perfusion. Mechanisms of endogenous H 2 S signaling are poorly understood; however, signal transmission is thought to occur via persulfidation at reactive cysteine residues on proteins. Although much has been discovered about how H 2 S is synthesized in the body, less is known about how it is metabolized. Recent studies have discovered a multitude of different targets for H 2 S therapy, including those related to protein modification, intracellular signaling, and ion channel depolarization. The most difficult part of studying hydrogen sulfide has been finding a way to accurately and reproducibly measure it. The purpose of this review is to: elaborate on the biosynthesis and catabolism of H 2 S in the human body, review current knowledge of the mechanisms of action of this gas in relation to ischemic injury, define strategies for physiological measurement of H 2 S in biological systems, and review potential novel therapies that use H 2 S for treatment.

AB - Hydrogen sulfide (H 2 S) is a novel signaling molecule most recently found to be of fundamental importance in cellular function as a regulator of apoptosis, inflammation, and perfusion. Mechanisms of endogenous H 2 S signaling are poorly understood; however, signal transmission is thought to occur via persulfidation at reactive cysteine residues on proteins. Although much has been discovered about how H 2 S is synthesized in the body, less is known about how it is metabolized. Recent studies have discovered a multitude of different targets for H 2 S therapy, including those related to protein modification, intracellular signaling, and ion channel depolarization. The most difficult part of studying hydrogen sulfide has been finding a way to accurately and reproducibly measure it. The purpose of this review is to: elaborate on the biosynthesis and catabolism of H 2 S in the human body, review current knowledge of the mechanisms of action of this gas in relation to ischemic injury, define strategies for physiological measurement of H 2 S in biological systems, and review potential novel therapies that use H 2 S for treatment.

KW - Hydrogen sulfide

KW - ischemia

KW - NaHS

KW - persulfidation

KW - polysulfide

UR - http://www.scopus.com/inward/record.url?scp=85030759327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030759327&partnerID=8YFLogxK

U2 - 10.1097/SHK.0000000000000894

DO - 10.1097/SHK.0000000000000894

M3 - Article

C2 - 28498298

AN - SCOPUS:85030759327

VL - 48

SP - 511

EP - 524

JO - Shock

JF - Shock

SN - 1073-2322

IS - 5

ER -