Hydrogen sulfide as an oxygen sensor

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Significance: Although oxygen (O2)-sensing cells and tissues have been known for decades, the identity of the O2-sensing mechanism has remained elusive. Evidence is accumulating that O2-dependent metabolism of hydrogen sulfide (H2S) is this enigmatic O2 sensor. Recent Advances: The elucidation of biochemical pathways involved in H2S synthesis and metabolism have shown that reciprocal H2S/O2 interactions have been inexorably linked throughout eukaryotic evolution; there are multiple foci by which O2 controls H2S inactivation, and the effects of H2S on downstream signaling events are consistent with those activated by hypoxia. H2S-mediated O2 sensing has been demonstrated in a variety of O2-sensing tissues in vertebrate cardiovascular and respiratory systems, including smooth muscle in systemic and respiratory blood vessels and airways, carotid body, adrenal medulla, and other peripheral as well as central chemoreceptors. Critical Issues: Information is now needed on the intracellular location and stoichometry of these signaling processes and how and which downstream effectors are activated by H2S and its metabolites. Future Directions: Development of specific inhibitors of H2S metabolism and effector activation as well as cellular organelle-targeted compounds that release H2S in a time- or environmentally controlled way will not only enhance our understanding of this signaling process but also provide direction for future therapeutic applications. Antioxid. Redox Signal. 22, 377-397. "Nothing in Biology Makes Sense Except in the Light of Evolution" - Theodosius Dobzhansky (29)

Original languageEnglish
Pages (from-to)377-397
Number of pages21
JournalAntioxidants and Redox Signaling
Volume22
Issue number5
DOIs
StatePublished - Feb 10 2015

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Oxygen sensors
Hydrogen Sulfide
Metabolism
Oxygen
Tissue
Respiratory system
Carotid Body
Cardiovascular system
Adrenal Medulla
Blood vessels
Metabolites
Cardiovascular System
Organelles
Respiratory System
Oxidation-Reduction
Smooth Muscle
Blood Vessels
Muscle
Vertebrates
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Hydrogen sulfide as an oxygen sensor. / Olson, Kenneth.

In: Antioxidants and Redox Signaling, Vol. 22, No. 5, 10.02.2015, p. 377-397.

Research output: Contribution to journalArticle

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