Hyperamylasemia After Post-Chemotherapy Retroperitoneal Lymph Node Dissection for Testis Cancer

Jack Baniel, Ilan Leibovitch, Richard Foster, Randall G. Rowland, Richard Bihrle, John P. Donohue

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Postoperative hyperamylasemia was evaluated in patients undergoing post-chemotherapy retroperitoneal lymph node dissection for testis cancer. Materials and Methods: Serum levels of amylase, lipase and bilirubin were evaluated prospectively in the immediate postoperative period in 39 consecutive patients who underwent post-chemotherapy retroperitoneal lymph node dissection. Results: Hyperamylasemia was found in 16 patients (41 percent), hyperlipasemia in 17 (43 percent) and hyperbilirubinemia in 9 (23 percent). Peak elevations were observed at 24 hours postoperatively and most returned to normal at 1 week. Elevation of these parameters was significantly associated with length and difficulty of the procedure. No patient demonstrated clinical acute pancreatitis. Conclusions: Extended retraction of the pancreas during post-chemotherapy retroperitoneal lymph node dissection may cause a minor reversible injury to the pancreas expressed as hyperamylasemia, hyperlipasemia and, rarely, jaundice. These findings are important to consider in the differential diagnosis of hyperamylasemia following post-chemotherapy retroperitoneal lymph node dissection.

Original languageEnglish
Pages (from-to)1373-1375
Number of pages3
JournalJournal of Urology
Volume154
Issue number4
DOIs
StatePublished - 1995

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Hyperamylasemia
Testicular Neoplasms
Lymph Node Excision
Drug Therapy
Pancreas
Hyperbilirubinemia
Amylases
Jaundice
Lipase
Bilirubin
Postoperative Period
Pancreatitis
Differential Diagnosis
Wounds and Injuries
Serum

ASJC Scopus subject areas

  • Urology

Cite this

Hyperamylasemia After Post-Chemotherapy Retroperitoneal Lymph Node Dissection for Testis Cancer. / Baniel, Jack; Leibovitch, Ilan; Foster, Richard; Rowland, Randall G.; Bihrle, Richard; Donohue, John P.

In: Journal of Urology, Vol. 154, No. 4, 1995, p. 1373-1375.

Research output: Contribution to journalArticle

Baniel, Jack ; Leibovitch, Ilan ; Foster, Richard ; Rowland, Randall G. ; Bihrle, Richard ; Donohue, John P. / Hyperamylasemia After Post-Chemotherapy Retroperitoneal Lymph Node Dissection for Testis Cancer. In: Journal of Urology. 1995 ; Vol. 154, No. 4. pp. 1373-1375.
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abstract = "Purpose: Postoperative hyperamylasemia was evaluated in patients undergoing post-chemotherapy retroperitoneal lymph node dissection for testis cancer. Materials and Methods: Serum levels of amylase, lipase and bilirubin were evaluated prospectively in the immediate postoperative period in 39 consecutive patients who underwent post-chemotherapy retroperitoneal lymph node dissection. Results: Hyperamylasemia was found in 16 patients (41 percent), hyperlipasemia in 17 (43 percent) and hyperbilirubinemia in 9 (23 percent). Peak elevations were observed at 24 hours postoperatively and most returned to normal at 1 week. Elevation of these parameters was significantly associated with length and difficulty of the procedure. No patient demonstrated clinical acute pancreatitis. Conclusions: Extended retraction of the pancreas during post-chemotherapy retroperitoneal lymph node dissection may cause a minor reversible injury to the pancreas expressed as hyperamylasemia, hyperlipasemia and, rarely, jaundice. These findings are important to consider in the differential diagnosis of hyperamylasemia following post-chemotherapy retroperitoneal lymph node dissection.",
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AU - Donohue, John P.

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N2 - Purpose: Postoperative hyperamylasemia was evaluated in patients undergoing post-chemotherapy retroperitoneal lymph node dissection for testis cancer. Materials and Methods: Serum levels of amylase, lipase and bilirubin were evaluated prospectively in the immediate postoperative period in 39 consecutive patients who underwent post-chemotherapy retroperitoneal lymph node dissection. Results: Hyperamylasemia was found in 16 patients (41 percent), hyperlipasemia in 17 (43 percent) and hyperbilirubinemia in 9 (23 percent). Peak elevations were observed at 24 hours postoperatively and most returned to normal at 1 week. Elevation of these parameters was significantly associated with length and difficulty of the procedure. No patient demonstrated clinical acute pancreatitis. Conclusions: Extended retraction of the pancreas during post-chemotherapy retroperitoneal lymph node dissection may cause a minor reversible injury to the pancreas expressed as hyperamylasemia, hyperlipasemia and, rarely, jaundice. These findings are important to consider in the differential diagnosis of hyperamylasemia following post-chemotherapy retroperitoneal lymph node dissection.

AB - Purpose: Postoperative hyperamylasemia was evaluated in patients undergoing post-chemotherapy retroperitoneal lymph node dissection for testis cancer. Materials and Methods: Serum levels of amylase, lipase and bilirubin were evaluated prospectively in the immediate postoperative period in 39 consecutive patients who underwent post-chemotherapy retroperitoneal lymph node dissection. Results: Hyperamylasemia was found in 16 patients (41 percent), hyperlipasemia in 17 (43 percent) and hyperbilirubinemia in 9 (23 percent). Peak elevations were observed at 24 hours postoperatively and most returned to normal at 1 week. Elevation of these parameters was significantly associated with length and difficulty of the procedure. No patient demonstrated clinical acute pancreatitis. Conclusions: Extended retraction of the pancreas during post-chemotherapy retroperitoneal lymph node dissection may cause a minor reversible injury to the pancreas expressed as hyperamylasemia, hyperlipasemia and, rarely, jaundice. These findings are important to consider in the differential diagnosis of hyperamylasemia following post-chemotherapy retroperitoneal lymph node dissection.

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