Hyperhomocysteinemia in renal transplant recipients

Allon N. Friedman, Irwin H. Rosenberg, Jacob Selhub, Andrew S. Levey, Andrew G. Bostom

Research output: Contribution to journalShort survey

40 Scopus citations

Abstract

Renal transplantation is a commonly performed curative procedure for end-stage renal disease. With the increase in renal allograft half-lives, attention is now being focused on cardiovascular morbidity and death in the renal transplant recipient (RTR) population. Among the more novel cardiovascular disease (CVD) risk factors for which this group is at risk is hyperhomocysteinemia. Hyperhomocysteinemia has been associated with an increased risk of CVD, although prospective randomized trials designed to prove causality are still ongoing. Since plasma total homocysteine levels are inversely related to renal function, RTRs have a greatly increased prevalence of hyperhomocysteinemia. Other determinants of homocysteine include B-vitamins, albumin, age, and genetic polymorphisms. Although RTRs are resistant to the typical B-vitamin doses used to correct hyperhomocysteinemia in the general population, they do respond to supraphysiologic dose therapy. In terms of prevalence, etiology, and treatment of hyperhomocysteinemia, RTRs are very similar to the much larger chronic renal insufficiency population. For this reason, RTRs have been chosen as an ideal study population in investigating the effect of reducing hyperhomocysteinemia on CVD outcomes.

Original languageEnglish (US)
Pages (from-to)308-313
Number of pages6
JournalAmerican Journal of Transplantation
Volume2
Issue number4
DOIs
StatePublished - Apr 1 2002
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Homocysteine
  • Kidney
  • Renal transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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