Hyperinsulinemia in African-American adolescents compared with their american white peers despite similar insulin sensitivity: A reflection of upregulated β-cell function?

Tamara Hannon, Fida Bacha, Yan Lin, Silva A. Arslanian

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

OBJECTIVE - African-American (AA) children are hyperinsulinemic and insulin resistant compared with American white (AW) children. Previously, we demonstrated that insulin secretion relative to insulin sensitivity was ∼75% higher in AA compared with AW children, suggesting that hyperinsulinemia in AA children is not merely a compensatory response to lower insulin sensitivity. The aim of the present investigation was to assess whether glucose-stimulated insulin response is higher in AA versus AW adolescents who have comparable in vivo insulin sensitivity. RESEARCH DESIGN AND METHODS - The hyperinsulinemic- euglycemic and hyperglycemic clamp techniques were utilized to assess first- and second-phase insulin secretion. Insulin secretion relative to insulin sensitivity was calculated as the glucose disposition index. RESULTS - AA adolescents compared with their AW peers with comparable insulin sensitivity and body composition had higher first-phase insulin concentrations. CONCLUSIONS - The quantitative relationship between insulin sensitivity and first-phase insulin appears to differ among AA and AW adolescents.

Original languageEnglish (US)
Pages (from-to)1445-1447
Number of pages3
JournalDiabetes Care
Volume31
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

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Hyperinsulinism
African Americans
Insulin Resistance
Insulin
Glucose
Glucose Clamp Technique
Body Composition
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Hyperinsulinemia in African-American adolescents compared with their american white peers despite similar insulin sensitivity : A reflection of upregulated β-cell function? / Hannon, Tamara; Bacha, Fida; Lin, Yan; Arslanian, Silva A.

In: Diabetes Care, Vol. 31, No. 7, 07.2008, p. 1445-1447.

Research output: Contribution to journalArticle

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