Hyperinsulinemia in polycystic ovary syndrome correlates with increased cardiovascular risk independent of obesity

Kieren Mather, Flora Kwan, Bernard Corenblum

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Objective: To assess the role of insulin resistance, independent of obesity, in determining cardiovascular risk among women with the polycystic ovarian syndrome (PCOS). Design: Cross-sectional study examining the relationships between hyperinsulinemia, composite cardiovascular risk scores, and prevalence of individual risk factors among lean and obese women with PCOS and healthy controls. Setting: University-based tertiary care outpatient endocrinology clinic. Patient(s): 57 women with clinically defined PCOS and 45 unselected healthy age-matched controls. Intervention(s): Clinical and anthropomorphic measurements and laboratory determinations of insulin and lipid levels. Main Outcome Measure(s): Fasting serum insulin and a cardiovascular risk score. Results: Hyperinsulinemic women with PCOS carried more cardiovascular risk than their normoinsulinemic counterparts, who in turn had more risk than the control women (P=.004 by analysis of covariance). In addition to the lipid changes expected with insulin resistance (high triglyceride and low HDL cholesterol levels), there was an excess of LDL cholesterol among the women with PCOS (P=.006 by analysis of covariance). Across the range of body mass index, women with PCOS had greater insulin resistance than controls, suggesting that PCOS itself and body mass index both contribute to the observed insulin resistance. Conclusions: Our data support the hypothesis that insulin resistance in PCOS is a determinant of overall cardiovascular risk independent of obesity. The mechanism of this relationship remains uncertain and is the subject of ongoing research.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalFertility and Sterility
Volume73
Issue number1
DOIs
StatePublished - Jan 2000
Externally publishedYes

Fingerprint

Polycystic Ovary Syndrome
Hyperinsulinism
Obesity
Insulin Resistance
Body Mass Index
Insulin
Lipids
Endocrinology
Tertiary Healthcare
Ambulatory Care Facilities
LDL Cholesterol
HDL Cholesterol
Fasting
Triglycerides
Cross-Sectional Studies
Outcome Assessment (Health Care)
Serum
Research

Keywords

  • Cardiovascular risk
  • Insulin resistance
  • Obesity
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Hyperinsulinemia in polycystic ovary syndrome correlates with increased cardiovascular risk independent of obesity. / Mather, Kieren; Kwan, Flora; Corenblum, Bernard.

In: Fertility and Sterility, Vol. 73, No. 1, 01.2000, p. 150-156.

Research output: Contribution to journalArticle

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