Hyperoxia improves contrast sensitivity in early diabetic retinopathy

Alon Harris, Oliver Arend, Ronald P. Danis, David Evans, Sebastian Wolf, Bruce J. Martin

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


Aim - The cause of vascular and visual pathology in diabetic retinopathy remains unknown. If retinal hypoxia plays a role, then early in the course of diabetes 100% oxygen breathing should normalise both contrast sensitivity and retinal blood flow. Methods - This hypothesis was tested in 12 diabetic patients with minimal retinopathy who, none the less, exhibited reduced contrast sensitivity (p = 0.003 versus 12 age and sex-matched controls) and prolonged retinal arteriovenous dye transit p = 0.0001 versus controls). Results - Isocapnic hyperoxia failed to alter contrast sensitivity in controls, while it significantly improved contrast sensitivity in patients (at 12 cpd; p = 0.042) to levels indistinguishable from normal. Individual improvement in contrast sensitivity correlated positively with the severity of the initial defect (r = + 0.84, p = 0.0008). Hyperoxia also had haemodynamic effects: it slowed retinal arteriovenous passage of fluorescein dye in controls, but did not further slow this transit time in patients. Conclusions - These results demonstrate the reversibility of early contrast sensitivity deficits in diabetes mellitus, and support the hypothesis that factors linked to tissue hypoxia initiate both visual and vascular dysfunction in diabetic retinopathy.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number3
StatePublished - Mar 1996

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Hyperoxia improves contrast sensitivity in early diabetic retinopathy'. Together they form a unique fingerprint.

Cite this