Hypertension and incident dementia in community-dwelling elderly Yoruba Nigerians

A. Ogunniyi, K. A. Lane, O. Baiyewu, Sujuan Gao, O. Gureje, Frederick Unverzagt, J. R. Murrell, V. Smith-Gamble, Kathleen Hall, Hugh Hendrie

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objectives- To investigate the relationship between hypertension and dementia incidence in community-dwelling elderly Yoruba (aged 70years and above) because of sparse information on dementia and its risk factors in developing countries. Materials and Methods- Community-based, prospective study of consenting elderly Yoruba using two-stage design. Blood pressure was measured during the baseline evaluation at 2001 and hypertension was defined as BP≥140/90mmHg. Diagnosis of dementia and normal cognition was by consensus using standard criteria. Non-demented subjects from the 2001 evaluation wave were re-evaluated during the 2004 and 2007 waves for dementia. Logistic regression was used to examine the association of baseline hypertension and incident dementia, after adjusting for age, gender, education, and histories of stroke and smoking. P-values <0.05 were considered significant. Results- During the 6-year follow-up, 120 individuals developed dementia, while 1633 remained non-demented. The frequency of hypertension in the demented group was significantly higher than in the non-demented (70.0% vs 60.2%, P=0.034). Baseline hypertension was a significant risk factor for dementia (OR=1.52; 95% CI 1.01-2.30). Higher systolic, diastolic or pulse pressure was associated with increased risk (P<0.05). Participants with diastolic BP≥90mmHg were at a significantly greater risk than those with readings below 70mmHg (OR=1.65; 95% CI 1.01-2.69). Conclusions- Hypertension was associated with increased risk of dementia in elderly Yoruba and its appropriate treatment may lower the risk.

Original languageEnglish
Pages (from-to)396-402
Number of pages7
JournalActa Neurologica Scandinavica
Volume124
Issue number6
DOIs
StatePublished - Dec 2011

Fingerprint

Independent Living
Dementia
Hypertension
Blood Pressure
Cognition
Developing Countries
Reading
Consensus
Logistic Models
Smoking
Stroke
Prospective Studies
Education
Incidence

Keywords

  • Dementia
  • Developing country
  • Higher cortical functions
  • Hypertension
  • Neurodegenerative diseases

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Hypertension and incident dementia in community-dwelling elderly Yoruba Nigerians. / Ogunniyi, A.; Lane, K. A.; Baiyewu, O.; Gao, Sujuan; Gureje, O.; Unverzagt, Frederick; Murrell, J. R.; Smith-Gamble, V.; Hall, Kathleen; Hendrie, Hugh.

In: Acta Neurologica Scandinavica, Vol. 124, No. 6, 12.2011, p. 396-402.

Research output: Contribution to journalArticle

Ogunniyi, A. ; Lane, K. A. ; Baiyewu, O. ; Gao, Sujuan ; Gureje, O. ; Unverzagt, Frederick ; Murrell, J. R. ; Smith-Gamble, V. ; Hall, Kathleen ; Hendrie, Hugh. / Hypertension and incident dementia in community-dwelling elderly Yoruba Nigerians. In: Acta Neurologica Scandinavica. 2011 ; Vol. 124, No. 6. pp. 396-402.
@article{f033112196d9475cb1b979ff14a95cc9,
title = "Hypertension and incident dementia in community-dwelling elderly Yoruba Nigerians",
abstract = "Objectives- To investigate the relationship between hypertension and dementia incidence in community-dwelling elderly Yoruba (aged 70years and above) because of sparse information on dementia and its risk factors in developing countries. Materials and Methods- Community-based, prospective study of consenting elderly Yoruba using two-stage design. Blood pressure was measured during the baseline evaluation at 2001 and hypertension was defined as BP≥140/90mmHg. Diagnosis of dementia and normal cognition was by consensus using standard criteria. Non-demented subjects from the 2001 evaluation wave were re-evaluated during the 2004 and 2007 waves for dementia. Logistic regression was used to examine the association of baseline hypertension and incident dementia, after adjusting for age, gender, education, and histories of stroke and smoking. P-values <0.05 were considered significant. Results- During the 6-year follow-up, 120 individuals developed dementia, while 1633 remained non-demented. The frequency of hypertension in the demented group was significantly higher than in the non-demented (70.0{\%} vs 60.2{\%}, P=0.034). Baseline hypertension was a significant risk factor for dementia (OR=1.52; 95{\%} CI 1.01-2.30). Higher systolic, diastolic or pulse pressure was associated with increased risk (P<0.05). Participants with diastolic BP≥90mmHg were at a significantly greater risk than those with readings below 70mmHg (OR=1.65; 95{\%} CI 1.01-2.69). Conclusions- Hypertension was associated with increased risk of dementia in elderly Yoruba and its appropriate treatment may lower the risk.",
keywords = "Dementia, Developing country, Higher cortical functions, Hypertension, Neurodegenerative diseases",
author = "A. Ogunniyi and Lane, {K. A.} and O. Baiyewu and Sujuan Gao and O. Gureje and Frederick Unverzagt and Murrell, {J. R.} and V. Smith-Gamble and Kathleen Hall and Hugh Hendrie",
year = "2011",
month = "12",
doi = "10.1111/j.1600-0404.2011.01491.x",
language = "English",
volume = "124",
pages = "396--402",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Hypertension and incident dementia in community-dwelling elderly Yoruba Nigerians

AU - Ogunniyi, A.

AU - Lane, K. A.

AU - Baiyewu, O.

AU - Gao, Sujuan

AU - Gureje, O.

AU - Unverzagt, Frederick

AU - Murrell, J. R.

AU - Smith-Gamble, V.

AU - Hall, Kathleen

AU - Hendrie, Hugh

PY - 2011/12

Y1 - 2011/12

N2 - Objectives- To investigate the relationship between hypertension and dementia incidence in community-dwelling elderly Yoruba (aged 70years and above) because of sparse information on dementia and its risk factors in developing countries. Materials and Methods- Community-based, prospective study of consenting elderly Yoruba using two-stage design. Blood pressure was measured during the baseline evaluation at 2001 and hypertension was defined as BP≥140/90mmHg. Diagnosis of dementia and normal cognition was by consensus using standard criteria. Non-demented subjects from the 2001 evaluation wave were re-evaluated during the 2004 and 2007 waves for dementia. Logistic regression was used to examine the association of baseline hypertension and incident dementia, after adjusting for age, gender, education, and histories of stroke and smoking. P-values <0.05 were considered significant. Results- During the 6-year follow-up, 120 individuals developed dementia, while 1633 remained non-demented. The frequency of hypertension in the demented group was significantly higher than in the non-demented (70.0% vs 60.2%, P=0.034). Baseline hypertension was a significant risk factor for dementia (OR=1.52; 95% CI 1.01-2.30). Higher systolic, diastolic or pulse pressure was associated with increased risk (P<0.05). Participants with diastolic BP≥90mmHg were at a significantly greater risk than those with readings below 70mmHg (OR=1.65; 95% CI 1.01-2.69). Conclusions- Hypertension was associated with increased risk of dementia in elderly Yoruba and its appropriate treatment may lower the risk.

AB - Objectives- To investigate the relationship between hypertension and dementia incidence in community-dwelling elderly Yoruba (aged 70years and above) because of sparse information on dementia and its risk factors in developing countries. Materials and Methods- Community-based, prospective study of consenting elderly Yoruba using two-stage design. Blood pressure was measured during the baseline evaluation at 2001 and hypertension was defined as BP≥140/90mmHg. Diagnosis of dementia and normal cognition was by consensus using standard criteria. Non-demented subjects from the 2001 evaluation wave were re-evaluated during the 2004 and 2007 waves for dementia. Logistic regression was used to examine the association of baseline hypertension and incident dementia, after adjusting for age, gender, education, and histories of stroke and smoking. P-values <0.05 were considered significant. Results- During the 6-year follow-up, 120 individuals developed dementia, while 1633 remained non-demented. The frequency of hypertension in the demented group was significantly higher than in the non-demented (70.0% vs 60.2%, P=0.034). Baseline hypertension was a significant risk factor for dementia (OR=1.52; 95% CI 1.01-2.30). Higher systolic, diastolic or pulse pressure was associated with increased risk (P<0.05). Participants with diastolic BP≥90mmHg were at a significantly greater risk than those with readings below 70mmHg (OR=1.65; 95% CI 1.01-2.69). Conclusions- Hypertension was associated with increased risk of dementia in elderly Yoruba and its appropriate treatment may lower the risk.

KW - Dementia

KW - Developing country

KW - Higher cortical functions

KW - Hypertension

KW - Neurodegenerative diseases

UR - http://www.scopus.com/inward/record.url?scp=80054896017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054896017&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0404.2011.01491.x

DO - 10.1111/j.1600-0404.2011.01491.x

M3 - Article

C2 - 21303353

AN - SCOPUS:80054896017

VL - 124

SP - 396

EP - 402

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 6

ER -