Hypertension Treatment for Patients with Advanced Chronic Kidney Disease

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Chronic kidney disease is common and frequently complicated with hypertension. As a major modifiable risk factor for cardiovascular disease in this high risk population, treatment of hypertension in chronic kidney disease is of paramount importance. We review the epidemiology and pathogenesis of hypertension in chronic kidney disease and then update the latest study results for treatment including salt restriction, invasive endovascular procedures, and pharmacologic therapy. Recent trials draw into question the efficacy of renal artery stenting or renal denervation for hypertension in chronic kidney disease, as well as renin-angiotensin-aldosterone system blockade as first line therapy of hypertension in end stage renal disease. Positive trial results reemphasize salt restriction and challenge the prevailing prejudice against the use of thiazide-like diuretics in advanced chronic kidney disease. Last, clinical practice guidelines are trending away from recommending tight blood pressure control in chronic kidney disease.

Original languageEnglish (US)
Article number400
JournalCurrent Cardiovascular Risk Reports
Volume8
Issue number10
DOIs
StatePublished - Oct 3 2014

Keywords

  • Chronic kidney disease
  • End stage renal disease
  • Hemodialysis
  • Hypertension
  • Resistant hypertension

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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