Hypertrophy of arteriolar smooth muscle cells in the rat small intestine during maturation

Bryan G. Miller, J. Marc Overhage, H. Bohlen, Andrew Evan

Research output: Contribution to journalArticle

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Abstract

The purpose of this study was to define structural characteristics for vascular smooth muscle (VSM) cells from the submucosal arteriolar system of the rat small intestine during maturation. Arterioles from 6- to 8-week-old and 10- to 12-week-old male WKY animals were selected from tissue prepared for scanning electron microscopy and mounted on end so that the entire circumference of each vessel could be observed by serial photography using scanning electron microscopy. From each vessel segment, the following measurements were made: (1) outer vessel diameter, (2) number of VSM cells occupying a length of vessel, (3) the number of resolutions each VSM cell makes around the vessel, (4) length of individual VSM cells, and (5) width of lateral processes along their length. At a given age, the length and width of the VSM cell was statistically similar for all types of arterioles. However, the VSM cell increased substantially in length and width from the 6-8- to 10-12-week time periods. The outer diameter for a particular arteriolar type also increased with age. These data suggest that the intestinal vasculature as a common population of smooth muscle cells at a given age in terms of their length, size, and process morphology for the various types of arterioles. Furthermore, maturation of the microvessels is associated with a uniform hypertrophy of the VSM cells from the majority of arterioles such that cells of young adult rats and those of juvenile animals represent distinctly different populations.

Original languageEnglish
Pages (from-to)56-69
Number of pages14
JournalMicrovascular Research
Volume29
Issue number1
DOIs
StatePublished - 1985

Fingerprint

Hypertrophy
Small Intestine
Smooth Muscle Myocytes
Muscle
Rats
Vascular Smooth Muscle
Cells
Arterioles
Electron Scanning Microscopy
Animals
Scanning electron microscopy
Photography
Microvessels
Population
Young Adult
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine

Cite this

Hypertrophy of arteriolar smooth muscle cells in the rat small intestine during maturation. / Miller, Bryan G.; Overhage, J. Marc; Bohlen, H.; Evan, Andrew.

In: Microvascular Research, Vol. 29, No. 1, 1985, p. 56-69.

Research output: Contribution to journalArticle

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