Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases

Leandro Piovan, Li Wu, Zhong Yin Zhang, Leandro H. Andrade

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Abstract

A series of organochalcogenanes was synthesized and evaluated as protein tyrosine phosphatases (PTPs) inhibitors. The results indicate that organochalcogenanes inactivate the PTPs in a time- and concentration-dependent fashion, most likely through covalent modification of the active site sulfur-moiety by the chalcogen atom. Consequently, organochalcogenanes represent a new class of mechanism-based probes to modulate the PTP-mediated cellular processes.

Original languageEnglish (US)
Pages (from-to)1347-1351
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number5
DOIs
StatePublished - Mar 1 2011

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases. / Piovan, Leandro; Wu, Li; Zhang, Zhong Yin; Andrade, Leandro H.

In: Organic and Biomolecular Chemistry, Vol. 9, No. 5, 01.03.2011, p. 1347-1351.

Research output: Contribution to journalArticle