Hypocholesterolemic activity of oryzanol in rats

G. S. Seetharamaiah, N. Chandrasekhara

Research output: Contribution to journalArticle

45 Scopus citations


The hypocholesterolemic activity of oryzanol isolated from rice brain oil has been investigated in rats fed one percent cholesterol in the diet. Feeding oryzanol for 3 weeks did not cause any lowering in serum chlesterol levels of rats fed cholesterol diet (CD) whereas after 5 weeks serum cholesterol levels were significantly reduced. When oryzanol was fed at 0.5% level for 7 weeks significant decreases were observed in serum total cholesterol as also in free, esterified and low density Lipoprotein (LDL))-cholesterol and triglycerides. In the group fed CD, the High density Lipoprotein (HDL)-cholesterol level decreased significantly when compared with the control group. Addition of oryzanol to CD did not alter the HDL cholesterol level. The increase in the level of low density lipoproteins (LDL) caused by feeding the cholesterol diet was significantly reversed in rats fed oryzanol along with cholesterol; this change was also reflected in a significant enhancement of the percentage of high density lipoproteins (HDL). There was no change in serum phsopholipid content. Liver total cholesterol, triglyceride and phospholipids also decreased significantly in rats fed 0.5% level of oryzanol.

Original languageEnglish (US)
Pages (from-to)927-935
Number of pages9
JournalNutrition Reports International
Issue number5
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Biochemistry
  • Endocrinology

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