Hypoglycemia in four dogs with smooth muscle tumors.

D. Beaudry, D. W. Knapp, T. Montgomery, George Sandusky, W. B. Morrison, R. W. Nelson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Tumor-associated hypoglycemia has been reported in dogs with pancreatic beta-cell tumors, hepatic tumors, and, rarely, with other neoplasms. This article describes 4 dogs with marked hypoglycemia associated with smooth muscle tumors (jejunal leiomyoma, gastric leiomyoma and leiomyosarcoma, and splenic leiomyosarcoma). Presenting clinical signs included grand mal seizures, lethargy, weakness, ataxia, and, in 1 dog, polyuria/polydipsia. The serum insulin concentration was low in 1 dog and normal in the other dog evaluated. Immunohistochemical staining for insulin was negative in the 4 tumors; the 3 tumors arising from the stomach and jejunum stained diffusely positive for glucagon. Blood glucose concentrations rapidly returned to normal after complete surgical resection of the tumors, and clinical signs associated with hypoglycemia resolved. Long-term follow-up available in 3 of the 4 dogs found no recurrence of clinical signs related to hypoglycemia at 15, 31, and 38 months after surgery, respectively.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume9
Issue number6
StatePublished - Nov 1995
Externally publishedYes

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Smooth Muscle Tumor
hypoglycemia
Hypoglycemia
smooth muscle
Dogs
neoplasms
dogs
Neoplasms
leiomyosarcoma
Leiomyosarcoma
Leiomyoma
Stomach
Insulin
stomach
insulin
Polydipsia
Polyuria
Lethargy
Insulinoma
Insulin-Secreting Cells

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Hypoglycemia in four dogs with smooth muscle tumors. / Beaudry, D.; Knapp, D. W.; Montgomery, T.; Sandusky, George; Morrison, W. B.; Nelson, R. W.

In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 9, No. 6, 11.1995, p. 415-418.

Research output: Contribution to journalArticle

Beaudry, D. ; Knapp, D. W. ; Montgomery, T. ; Sandusky, George ; Morrison, W. B. ; Nelson, R. W. / Hypoglycemia in four dogs with smooth muscle tumors. In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine. 1995 ; Vol. 9, No. 6. pp. 415-418.
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