Hypothalamic obesity syndrome: Rare presentation of CNS+ B-cell lymphoblastic lymphoma

Troy C. Quigg, Nadine G. Haddad, Jeffrey C. Buchsbaum, Chie Schin Shih

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Hypothalamic obesity syndrome can affect brain tumor patients following surgical intervention and irradiation. This syndrome is rare at diagnosis in childhood cancer, but has been reported with relapse of acute lymphoblastic leukemia. Here we present a case of hypothalamic obesity syndrome as the primary presentation of a toddler found to have CNS+ B-cell lymphoblastic lymphoma. Cytogenetic studies on diagnostic cerebrospinal fluid revealed MLL gene rearrangement (11q23). Hyperphagia and obesity dramatically improved following induction and consolidation chemotherapy. We describe a novel presentation of hypothalamic obesity syndrome in CNS B-cell lymphoblastic lymphoma, responsive to chemotherapy.

Original languageEnglish (US)
Pages (from-to)930-933
Number of pages4
JournalPediatric Blood and Cancer
Issue number5
StatePublished - Nov 2012


  • Hyperphagia
  • Hypothalamic obesity syndrome
  • Precursor B-cell lymphoblastic lymphoma

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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