Hypothalamic obesity syndrome

Rare presentation of CNS+ B-cell lymphoblastic lymphoma

Troy C. Quigg, Nadine G. Haddad, Jeffrey C. Buchsbaum, Chie-Schin Shih

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hypothalamic obesity syndrome can affect brain tumor patients following surgical intervention and irradiation. This syndrome is rare at diagnosis in childhood cancer, but has been reported with relapse of acute lymphoblastic leukemia. Here we present a case of hypothalamic obesity syndrome as the primary presentation of a toddler found to have CNS+ B-cell lymphoblastic lymphoma. Cytogenetic studies on diagnostic cerebrospinal fluid revealed MLL gene rearrangement (11q23). Hyperphagia and obesity dramatically improved following induction and consolidation chemotherapy. We describe a novel presentation of hypothalamic obesity syndrome in CNS B-cell lymphoblastic lymphoma, responsive to chemotherapy.

Original languageEnglish
Pages (from-to)930-933
Number of pages4
JournalPediatric Blood and Cancer
Volume59
Issue number5
DOIs
StatePublished - Nov 2012

Fingerprint

B-Cell Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Obesity
Consolidation Chemotherapy
Hyperphagia
Induction Chemotherapy
Gene Rearrangement
Brain Neoplasms
Cytogenetics
Cerebrospinal Fluid
Recurrence
Drug Therapy
Neoplasms

Keywords

  • Hyperphagia
  • Hypothalamic obesity syndrome
  • Precursor B-cell lymphoblastic lymphoma

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Hypothalamic obesity syndrome : Rare presentation of CNS+ B-cell lymphoblastic lymphoma. / Quigg, Troy C.; Haddad, Nadine G.; Buchsbaum, Jeffrey C.; Shih, Chie-Schin.

In: Pediatric Blood and Cancer, Vol. 59, No. 5, 11.2012, p. 930-933.

Research output: Contribution to journalArticle

Quigg, Troy C. ; Haddad, Nadine G. ; Buchsbaum, Jeffrey C. ; Shih, Chie-Schin. / Hypothalamic obesity syndrome : Rare presentation of CNS+ B-cell lymphoblastic lymphoma. In: Pediatric Blood and Cancer. 2012 ; Vol. 59, No. 5. pp. 930-933.
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