Hypothetical quantitative trait loci (QTL) for circadian period of locomotor activity in CXB recombinant inbred strains of mice

Aimee R. Mayeda, John R. Hofstetter, John K. Belknap, John I. Nurnberger

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The locomotor activity of male mice (Mus musculus) of 13 CXB (BALB/cBy x C57BL/6J) recombinant inbred (RI) strains and their progenitor strains was monitored for 4 to 6 weeks by infrared photoelectric beams under constant dark. The circadian period (τ) of locomotor activity was calculated and used in quantitative trait locus (QTL) analysis of strains' means. Results were compared with potential QTL found in a previous study of the BXD RI series. The mean τ of 13 CXB RI mouse strains (three to six animals per strain) in constant dark had a unimodal distribution suggesting polygenic inheritance. A number of potential QTL were found for this trait. There were two associations at p < .001, H23 on chromosome 3 and Pmv16 on chromosome 16. A region of chromosome 1 was associated with τ in both CXB and BXD RI series. There was also a conjunction with a locus determined from QTL analysis of the previously reported τ of wheel running activity in seven CXB RI strains (Schwartz and Zimmerman, 1990).

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalBehavior Genetics
Volume26
Issue number5
DOIs
StatePublished - Sep 1 1996

Keywords

  • circadian rhythms
  • genetics
  • Inbred mouse
  • locomotor activity
  • quantitative trait loci

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

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