HypoxamiRs and cancer

From biology to targeted therapy

Harriet E. Gee, Cristina Ivan, George A. Calin, Mircea Ivan

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Significance: Hypoxia is a hallmark of the tumor microenvironment and represents a major source of failure in cancer therapy. Recent Advances: Recent work has generated extensive evidence that microRNAs (miRNAs) are significant components of the adaptive response to low oxygen in tumors. Induction of specific miRNAs, collectively termed hypoxamiRs, has become an accepted feature of the hypoxic response in normal and transformed cells. Critical Issues: Overexpression of miR-210, the prototypical hypoxamiR, is detected in most solid tumors, and it has been linked to adverse prognosis in many tumor types. Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth. Additional miRNAs are modulated by decreased oxygen tension in a more tissue-specific fashion, adding another level of complexity over the classic hypoxia-regulated gene network. Future Directions: From a biological standpoint, hypoxamiRs are emerging modifiers of cancer cell response to the adaptive challenges of the microenvironment. From a clinical perspective, assessing the status of these miRNAs may contribute to a detailed understanding of hypoxia-induced mechanisms of resistance and/or to the fine-tuning of future hypoxia-modifying therapies. Antioxid. Redox Signal. 21, 1220-1238.

Original languageEnglish
Pages (from-to)1220-1238
Number of pages19
JournalAntioxidants and Redox Signaling
Volume21
Issue number8
DOIs
StatePublished - Sep 10 2014

Fingerprint

Tumors
MicroRNAs
Neoplasms
sulofenur
Genes
Oxygen
Glycerolphosphate Dehydrogenase
Therapeutics
Tumor Microenvironment
Sulfur
Scaffolds
Gene Regulatory Networks
Iron
Tuning
Oxidation-Reduction
Cells
Tissue
Down-Regulation
Hypoxia
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry
  • Medicine(all)

Cite this

HypoxamiRs and cancer : From biology to targeted therapy. / Gee, Harriet E.; Ivan, Cristina; Calin, George A.; Ivan, Mircea.

In: Antioxidants and Redox Signaling, Vol. 21, No. 8, 10.09.2014, p. 1220-1238.

Research output: Contribution to journalArticle

Gee, Harriet E. ; Ivan, Cristina ; Calin, George A. ; Ivan, Mircea. / HypoxamiRs and cancer : From biology to targeted therapy. In: Antioxidants and Redox Signaling. 2014 ; Vol. 21, No. 8. pp. 1220-1238.
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