Hypoxia-Ischemia-Induced Apoptotic Cell Death Correlates with IGF-I mRNA Decrease in Neonatal Rat Brain

Teresa F. Clawson, Susan J. Vannucci, Guo Ming Wang, Lisa B. Seaman, Xian Lin Yang, Wei Hua Lee

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Hypoxia-ischemia induces apoptotic and necrotic cell death, which results partially from persistent alterations in cellular energy homeostasis. Insulin-like growth factor I (IGF-I) is an anabolic pleiotrophic factor required by developing neurons for their optimal proliferation, differentiation, and survival. To determine how cell death and changes in IGF-I gene expression relate to the extent of hypoxia-ischemia, we evaluated the time course of apoptosis in a neonatal hypoxia-ischemia model in relation to the cellular distribution of IGF-I and IGFBP5 mRNA. Severe hypoxia-ischemia results in an immediate decrease in neuronal IGF-I and IGFBP5 mRNA. The decrease in neuronal IGF-I mRNA was concurrent with an increase in the number of apoptotic cells. It is conceivable that the immediate decrease in IGF-I gene expression may contribute to the impending neuronal death and selective vulnerability of myelinogenesis during the perinatal period.

Original languageEnglish (US)
Pages (from-to)281-293
Number of pages13
JournalNeuroSignals
Volume8
Issue number4-5
DOIs
StatePublished - Sep 13 1999

Keywords

  • Apoptosis
  • Brain
  • Hypoxia-ischemia
  • IGF-I

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Clawson, T. F., Vannucci, S. J., Wang, G. M., Seaman, L. B., Yang, X. L., & Lee, W. H. (1999). Hypoxia-Ischemia-Induced Apoptotic Cell Death Correlates with IGF-I mRNA Decrease in Neonatal Rat Brain. NeuroSignals, 8(4-5), 281-293. https://doi.org/10.1159/000014599