Hypoxia-ischemia-induced apoptotic cell death correlates with IGF-I mRNA decrease in neonatal rat brain

T. F. Clawson, S. J. Vannucci, G. M. Wang, L. B. Seaman, X. L. Yang, W. H. Lee

Research output: Contribution to journalArticle

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Abstract

Hypoxia-ischemia induces apoptotic and necrotic cell death, which results partially from persistent alterations in cellular energy homeostasis. Insulin-like growth factor I (IGF-I) is an anabolic pleiotrophic factor required by developing neurons for their optimal proliferation, differentiation, and survival. To determine how cell death and changes in IGF-I gene expression relate to the extent of hypoxia-ischemia, we evaluated the time course of apoptosis in a neonatal hypoxia-ischemia model in relation to the cellular distribution of IGF-I and IGFBP5 mRNA. Severe hypoxia-ischemia results in an immediate decrease in neuronal IGF-I and IGFBP5 mRNA. The decrease in neuronal IGF-I mRNA was concurrent with an increase in the number of apoptotic cells. It is conceivable that the immediate decrease in IGF-I gene expression may contribute to the impending neuronal death and selective vulnerability of myelinogenesis during the perinatal period.

Original languageEnglish
Pages (from-to)281-293
Number of pages13
JournalBiological Signals and Receptors
Volume8
Issue number4-5
StatePublished - 1999

Fingerprint

Cell death
Insulin-Like Growth Factor I
Rats
Brain
Cell Death
Ischemia
Messenger RNA
Gene expression
Gene Expression
Neurons
Hypoxia
Homeostasis
Cell Count
Cells
Apoptosis

Keywords

  • Apoptosis
  • Brain
  • Hypoxia-ischemia
  • IGF-I

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Clawson, T. F., Vannucci, S. J., Wang, G. M., Seaman, L. B., Yang, X. L., & Lee, W. H. (1999). Hypoxia-ischemia-induced apoptotic cell death correlates with IGF-I mRNA decrease in neonatal rat brain. Biological Signals and Receptors, 8(4-5), 281-293.

Hypoxia-ischemia-induced apoptotic cell death correlates with IGF-I mRNA decrease in neonatal rat brain. / Clawson, T. F.; Vannucci, S. J.; Wang, G. M.; Seaman, L. B.; Yang, X. L.; Lee, W. H.

In: Biological Signals and Receptors, Vol. 8, No. 4-5, 1999, p. 281-293.

Research output: Contribution to journalArticle

Clawson, TF, Vannucci, SJ, Wang, GM, Seaman, LB, Yang, XL & Lee, WH 1999, 'Hypoxia-ischemia-induced apoptotic cell death correlates with IGF-I mRNA decrease in neonatal rat brain', Biological Signals and Receptors, vol. 8, no. 4-5, pp. 281-293.
Clawson, T. F. ; Vannucci, S. J. ; Wang, G. M. ; Seaman, L. B. ; Yang, X. L. ; Lee, W. H. / Hypoxia-ischemia-induced apoptotic cell death correlates with IGF-I mRNA decrease in neonatal rat brain. In: Biological Signals and Receptors. 1999 ; Vol. 8, No. 4-5. pp. 281-293.
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